Lowe Down


  • Process Development

    Signing Off!

    After 15 years, the Lowe Down column has come to a close
    Derek B. Lowe, Contributing Editor 06.02.15

  • Chemistry Automation

    How machine integration in the lab is changing the traditional role of the chemist
    Derek B. Lowe, Contributing Editor 05.06.15

  • What’s Your Chemistry?

    Overcoming drug discovery hurdles
    Derek B. Lowe, Contributing Editor 04.01.15

  • Chemical Intuition

    Sorting through compounds in the lab is a tricky business
    Derek B. Lowe, Contributing Editor 03.06.15

  • Back To School

    How much science education is necessary for non-science professionals?
    Derek B. Lowe, Contributing Editor 01.29.15

  • Drug Discovery and Public Perception

    These are two worlds that certainly don’t see eye-to-eye.
    Derek B. Lowe, Contributing Editor 11.13.14

  • Riding the Outsourcing Wave

    Trends have come and gone, but where is the industry going?
    Derek B. Lowe, Contributing Editor 10.14.14

  • Improving Our Aim

    Lack of efficacy, and poor toxicity, are major problems in lead generation today. How can we solve them?
    Derek B. Lowe, Contributing Editor 09.08.14

  • Welcome To MegaBioPharm

    Where progress is our only problem
    Derek B. Lowe, Contributing Editor 07.21.14

  • Giving Nature a Boost

    Imagine the possibilities if the best of chemical synthesis could be used to control or optimize enzymatic activity
    Derek B. Lowe, Contributing Editor 06.03.14

  • One Hit Wonders

    Most drug companies will only have one successful drug during their lifetimes, and that is probably a good thing.
    Derek B. Lowe, Contributing Editor 05.01.14

  • Beware of Pharma’s Perverse Incentives

    What cannot be measured cannot be managed, but let’s measure the right things, correctly, or we’ll only encourage the counterproductive.
    Derek B. Lowe, Contributing Editor 04.03.14

  • Signal to Noise

    Let’s take inventory. The FDA approved 37 drugs in 2012, which made everyone happy, since it was the highest total in years. But then in 2013, the agency only approved 27, which occasioned quite a few columns and blog posts wondering if 2012 wa…
    Derek B. Lowe, Contributing Editor 03.07.14

  • Take It to the Next Level!

    I always hesitate before starting out a sentence with the “There are two types of people in the world . . .” line, because in my head, I always complete it with “. . . people who divide the world into two types of people, and peopl…
    Derek B. Lowe, Contributing Editor 01.24.14

  • Tell Me What I Want To Hear

    Stated vs. revealed preferences
    Derek B. Lowe, Contributing Editor 10.09.13

  • Rules for Discovery

    Wisdom from the early phase
    Derek B. Lowe, Contributing Editor 09.05.13

  • Work on Your Own

    Let me take you on a quick nostalgia trip, back to an earlier day in pharma research. Do you remember when some companies used to actively boast that they encouraged their scientists to devote x% of their time to working on their own ideas? Whether t…
    Derek B. Lowe, Contributing Editor 06.05.13

  • What Does this Compound Do?

    One question, many answers
    Derek B. Lowe, Contributing Editor 05.06.13

  • Timelines and Timeliness

    What happens when money stands still?
    Derek B. Lowe, Contributing Editor 03.06.13

  • Age-Related Disorder

    When much is taken, how much abides?
    Derek B. Lowe, Contributing Editor 01.22.13