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Related Searches: Development Tablet formulation Dosage
May 8, 2015
The objective of this study was to achieve the drug release rate which is independent of time and the concentration from a solid oral tablet dosage form. A zero order, pH independent release formulation for a freely water soluble model drug (Buspiron…  Read More »
May 8, 2015
The objective of this study was to evaluate a novel technique for compressing blends at low temperatures using Vortex Coolers. Processing of low melting APIs or excipients such as solubilizers/bioavailability enhancers into a tablet dosage form has b…  Read More »
May 8, 2015
The purpose of this study was to evaluate the development of oral fast disintegrating tablets by conventional direct compression method and statistical design of experiment. Better results were obtained with lower strength than higher strength tablet…  Read More »
May 8, 2015
The purpose of this study was to compare the reliability and reproducibility of manual and automated dissolution-UV methods. Extended-release acetaminophen was selected as the model. This study demonstrated that the fiber optic probe system was prefe…  Read More »
May 8, 2015
The purpose of this study was to investigate the effect of wet granulation factors on the compression behaviour and other physical characteristics of a slow release polymeric matrix formulation. The water quantity used for granulation was the most im…  Read More »
May 8, 2015
The purpose of this study was to evaluate the use of a true placebo DoE to create a platform process in which to define a viable active formulation process on a roller compactor. The use of placebo DoE was effective in creating a platform process for…  Read More »
May 8, 2015
The purpose of this work was to study the use of LIBS (Laser Induced Breakdown Spectroscopy) as an in-process monitor for uniformity during an API tablet coating process. In-process measurements were taken up to the coating endpoint, and evaluated to…  Read More »
May 8, 2015
The purpose of this study was to develop and optimize a Wurster fluid-bed coating process for applying an enteric coating onto empty hypromellose capsule caps and bodies to achieve acid resistance after filling. Coated capsules were manually filled a…  Read More »
May 8, 2015
The purpose of this study was to establish the design space and operational conditions for the roller compaction process of a placebo formulation that closely represents a low-dose active formulation. The ribbon density, tensile strength, mean granul…  Read More »
May 8, 2015
The purpose of this study is to further optimize and assess the effect of refining magnesium stearate lubricant, sweetener, hardness and thickness levels on the design of a fast disintegrating formulation by direct compression.…  Read More »
May 8, 2015
The purpose of this study was to investigate the root cause and potential mechanism behind the areas of discoloration on stability samples of pharmaceutical tablets. The most likely mechanism of tablet discoloration was related to a dehydration react…  Read More »
May 8, 2015
The purpose of this study was to understand the roller compaction behavior of different model placebo formulations using smooth rolls and to compare their performance against different roll surfaces. This study clearly demonstrates the differences in…  Read More »
May 8, 2015
The purpose of this study was to evaluate the incidence of cracking of gelatin capsules filled with commercially viable examples of hygroscopic placebo formulations and low viscosity hydrophobic liquids.…  Read More »
May 8, 2015
The purpose of this study was to evaluate the HPMC banding process and morphology using different banding agents, and compare HPMC banding and regular gelatin banding processes and to look for a possible new water based HPMC banding process and bandi…  Read More »
May 8, 2015
The purpose of this study was to determine critical process parameters which influence the characteristics of spray dried materials for quick small scale formulation screening using DOE. Cconcentration of the spray dry solution can significantly affe…  Read More »



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