Absorption Systems is working with Drs. Ken Korzekwa and Swati Nagar of Temple University and Dr. Jeff Jones of Washington State University to develop technologies to improve the predictive power of certain in vitro-in vivo correlations (IVIVCs).

The collaboration will focus specifically on the prediction of pharmacokinetics (PK), an area in which Absorption Systems will contribute its expertise. The academic partners in this collaboration will develop mathematical models based on in vitro data generated by Absorption Systems.

Absorption Systems is providing experimental test systems, data, and expertise in permeability and transporters. Using computer simulations, Drs. Korzekwa, Nagar, and Jones are developing models to predict the extent of involvement of various clearance processes for a structurally diverse set of drugs.  

Dr. Ken Korzekwa, associate professor, School of Pharmacy, Temple University, said, “We anticipate that this research will result in improved methods that can be used broadly within the industry to predict a number of PK parameters and potential drug-drug interactions.”

Dr. Ismael Hidalgo, chief scientist of Absorption Systems, said, “We look forward to collaborating with our academic research colleagues in this important project, which we expect will lead to the creation of tools of great practical value.”