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X-Chem Achieves Bayer Milestone

By Kristin Brooks | February 13, 2014

Licenses early-stage discovery program against an epigenetic drug target

X-Chem, Inc. has achieved a milestone under its multi-target collaboration with Bayer Pharma AG. Bayer is licensing an early-stage drug discovery program directed against an epigenetic drug target, which has shown promise as an emerging therapeutic option for cancer and other diseases. While identifying small molecule inhibitors for these targets is considered technologically challenging, X-Chem’s product engine has proven effective for discovering novel and selective inhibitors to multiple classes of targets.
X-Chem received an upfront payment and ongoing research funding to apply its DNA-encoded small molecule library and discovery engine for the identification of novel leads to several Bayer targets. Bayer has an exclusive option to license programs generated under the collaboration. For each program Bayer licenses, X-Chem will receive an upfront exercise fee in addition to preclinical, clinical and sales milestone payments, as well as royalties. Financial terms were not disclosed.
“We recognize the innovative potential of X-Chem’s team and technology platform,” said Dr. Hanno Wild, senior vice president and head of Candidate Generation & Exploration at Bayer HealthCare Global Drug Discovery. “We look forward to continuing to work with X-Chem.”
“We share Bayer’s mission to bring innovative treatments to patients by addressing disease areas with a high unmet medical need. Epigenetic targets are of increasing interest for treating cancer and other life-threatening disorders, yet are particularly challenging from a drug discovery perspective,” said Rick Wagner, Ph.D., chief executive officer of X-Chem. “X-Chem has built its library and discovery platform to meet the challenges of tackling these highly difficult targets and enabling the discovery of multiple chemical series directly out of our primary screens.”

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