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Last Updated Saturday, October 25 2014
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Astex Earns Novartis Milestone



By Kristin Brooks



Published March 5, 2014
Related Searches: Preclinical Phase III
Astex Pharmaceuticals has received a milestone payment from Novartis for the commencement, by Novartis, of a Phase III trial of LEE011, a small-molecule inhibitor of cyclin-dependent kinases (CDK) 4 and 6 in postmenopausal woman with advanced breast cancer. LEE011 was discovered under a drug discovery collaboration between Astex and Novartis initiated in December 2005.
 
LEE011 inhibits CDK4 and CDK6 leading to cell cycle arrest and suppression of DNA synthesis, which may inhibit cancer cell growth. LEE011, in combination with other agents, has shown promising activity in preclinical studies in melanoma and breast cancer.
 


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