Breaking News

Astex Earns Novartis Milestone

By Kristin Brooks | March 5, 2014

Initiates Phase III trial of LEE011 in advanced breast cancer

Astex Pharmaceuticals has received a milestone payment from Novartis for the commencement, by Novartis, of a Phase III trial of LEE011, a small-molecule inhibitor of cyclin-dependent kinases (CDK) 4 and 6 in postmenopausal woman with advanced breast cancer. LEE011 was discovered under a drug discovery collaboration between Astex and Novartis initiated in December 2005.
 
LEE011 inhibits CDK4 and CDK6 leading to cell cycle arrest and suppression of DNA synthesis, which may inhibit cancer cell growth. LEE011, in combination with other agents, has shown promising activity in preclinical studies in melanoma and breast cancer.
 

Related Contract Manufacturing:

  • CROs and Today’s  R&D Landscape

    CROs and Today’s R&D Landscape

    Kristin Brooks, Associate Editor, Contract Pharma||November 9, 2016
    John Lewis of ACRO discusses opportunities, challenges, and the future CRO

  • The Human Parts of Mouse Models

    The Human Parts of Mouse Models

    Julia Schueler, Head of in vivo Operations, Oncotest, a Charles River company ||October 11, 2016
    The PDX model system has come back into focus

  • Choosing Oral Formulations for First-in-man Clinical Trials

    Choosing Oral Formulations for First-in-man Clinical Trials

    Jon Sutch, Senior Manager of Formulation Development, Patheon||October 11, 2016
    Early formulations should be simple, but selecting a simple formulation isn’t as easy as it seems