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Do Phthalates Leach Out of Metered-Dose Inhalers?

April 2, 2014

Chinese researchers are exploring potential patient risks from phthalate leaching out of metered-dose inhalers.

According to, Chinese researchers at the Shanghai Institute of Pharmaceutical Industry and the Shanghai Institute for Food and Drug Control are using analytical techniques to study whether phthalate esters leach out of plastic metered-dose inhalers.  Using gas chromatography and mass spectrometry, they monitored levels of  21 different phthalate esters. Findings suggest that inhalers do not leach phthalates to a level above the daily recommended limit, but still "add to the phthalate load that patients already endure."