Takeda was ordered to pay $6 billion in punitive damages and its partner Eli Lilly & Co. was ordered to pay $3 billion. Takeda and Lilly plan to contest the verdict, which is likely to result in reduced fines. Takeda developed and manufactured Actos and Lilly marketed the drug in the U.S. and Canada.
In 2011, the FDA claimed that use of Actos for more than a year may be associated with heightened risk for bladder cancer. At that time, regulators in France and Germany suspended sales of Actos over health concerns.