Breaking News

Agenus, Merck in Antibody Development Pact

April 28, 2014

To develop therapeutic antibodies for cancer treatments

Agenus Inc. has entered into a collaboration and license agreement with Merck for the discovery and development of therapeutic antibodies to immune checkpoints for cancer treatments. Agenus will be responsible for discovery and optimization of fully human antibodies against two undisclosed Merck targets using the 4-Antibody Retrocyte Display platform. Merck will be responsible for clinical development and commercialization.
 
Agenus is eligible to receive approximately $100 million in payments associated with the clinical, regulatory and commercial milestones for two candidates, as well as royalties on worldwide product sales.
 
“We are delighted to be working with Merck, who is a leader in the rapidly developing immuno-oncology space," said Bob Stein, MD, Ph.D., chief scientific officer of Agenus. "We believe our Retrocyte Display technology has significant advantages for creation of high quality antibody development candidates. This collaboration broadens our efforts in immuno-oncology beyond our previously disclosed checkpoint programs with a world-class research and development partner."
 
“This collaboration with Agenus complements our active immuno-oncology discovery programs,” said Dr. Eric Rubin, vice president clinical oncology, Merck Research Laboratories. “We look forward to working to advance these programs with the potential to address the unmet medical needs of people with cancer.”

Related Contract Manufacturing:

blog comments powered by Disqus
  • Limiting APIs in Manufacturing Effluent

    Limiting APIs in Manufacturing Effluent

    Joan Tell, Robert Drinane, Bruce Naumann, Jessica Vestel, and Gregory Gagliano, Merck & Co., Inc.||June 2, 2016
    An approach for setting limits on pharmaceuticals discharged in manufacturing effluent

  • Successful Method Transfer of Solid Oral Dosage

    Successful Method Transfer of Solid Oral Dosage

    John Frankonis, Ropack Pharma Solutions||June 2, 2016
    The three steps outlined will help guide the process of completing a successful analytical method transfer

  • Who’s the Right Service Provider for You?

    Who’s the Right Service Provider for You?

    Raymond Peck, VxP Pharma Services||June 2, 2016
    Factors to consider when choosing between using one integrated CDMO or a series of smaller functional service providers