The companies entered a collaboration for the joint development and commercialization of filgotinib in inflammatory diseases in December 2015. Galapagos co-funds 20% of global development activities and Gilead is responsible for manufacturing and worldwide marketing and sales activities. Galapagos has the option to co-promote filgotinib in the UK, Germany, France, Italy, Spain, Belgium, the Netherlands and Luxembourg, in which case the companies will share profits. Galapagos is entitled to an upfront payment of $725 million, consisting of a license fee of $300 million and a $425 million equity investment. In addition, Galapagos is eligible for payments of as much as $1.35 billion in milestones, with royalties and a profit split in co-promotion territories.