Inflammasomes are important signaling complexes that play a critical role in innate immunity, the body’s first line of defense against foreign infectious organisms and cell damage. However, overactivation of inflammasomes lead to chronic debilitating inflammatory diseases, such as multiple sclerosis and diabetic kidney disease. ZyVersa’s IC 100 is a monoclonal antibody that inhibits the adaptor ASC (apoptosis-associated speck-like protein containing a caspase recruitment domain), component of multiple inflammasomes. By inhibiting ASC, IC 100 blocks inflammasome formation and initiation of the inflammatory cascade. By inhibiting the ASC component of ASC Specks, IC 100 disrupts ASC Speck structure and function, thereby inhibiting perpetuation of the massive inflammatory response. Via these mechanisms of action, IC 100 is expected to significantly reduce inflammation contributing to a broad group of inflammatory disorders.
“ZyVersa’s approach to inflammasome inhibition is unique and has the potential to more effectively reduce the inflammation that occurs in patients with inflammatory diseases than product candidates in development that are targeting NLRP3,” said Igor Fisch, chief executive officer, Selexis SA.
Tim Kelly, president and chief executive officer, KBI Biopharma, said, “We are excited to partner with ZyVersa on their innovative IC 100 program. It’s an ideal opportunity to leverage our fully integrated offering to advance IC 100 into clinical studies while delivering a robust, scalable process and a thoroughly characterized, stable and potent product. Together, Selexis and KBI provide a truly unique solution for ZyVersa and all biopharma companies who are bringing the next generation of therapies to patients.”
Selexis’ expertise in mammalian cell line generation along with KBI Biopharma’s proven strengths in process development and analytics fuel their integrated development approach. This unparalleled platform starts with DNA transfection and ends with GMP drug substance in as little as nine months, allowing predictable delivery of material to partners for clinical study and achieving faster time-to-market with lower manufacturing costs.