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Triphase Accelerator Initiates Phase I Trial of TRPH-222


Next-Gen Antibody-Drug Conjugate developed using Catalent’s SMARTag ADC Technology

Triphase Accelerator, a company dedicated to acquiring and developing cancer therapeutics, initiated a Phase I trial of TRPH-222, an anti-CD22 antibody-drug conjugate (ADC) for the treatment of patients with lymphoma. TRPH-222 was originally developed by Catalent’s subsidiary Redwood Bioscience, Inc. using the  SMARTag platform, which provides optimized site-specific protein-modification and linker technologies. Triphase Accelerator obtained worldwide rights to further develop this program and subsequently announced that Celgene had obtained the option to acquire all rights to the program as part of an expanded strategic collaboration.
The Phase I clinical trial is a multi-center, open-label study of TRPH-222 monotherapy in subjects with relapsed and/or refractory B-cell non-Hodgkin lymphoma (NHL), which will be conducted in two stages, dose-escalation and dose-expansion. 
“We are thrilled to advance the first SMARTag ADC into human clinical trials and evaluate its potential for better tolerability and an expanded therapeutic index as compared to conventional ADCs” said Dr. Mathias Schmidt, executive vice president and head of R&D of Triphase Accelerator. “We look forward to assessing the potential clinical benefit of TRPH-222 in patients with relapsed/refractory B-cell lymphoma and remain convinced that this molecule can play an important role in the future treatment of lymphoma.”
”We are excited to see Triphase Accelerator reach this important milestone with TRPH-222,” added Mike Riley, vice president and general manager, Catalent Biologics. “The SMARTag technology has the potential to create ADCs with significantly higher tolerability and expanded therapeutic index. The improved conjugate stability and biophysical characteristics of TRPH-222 has translated to improved tolerability in preclinical testing, and we look forward to further validation in the clinic.”