While implementing a successful serialization strategy involves many complex and inter-dependent steps, they are not insurmountable, as early-adopters are finding. Much has been written already on the tactical demands of preparing packaging lines and sites for serialized production but many pharmaceutical organizations are either unaware or underestimate one of the biggest challenges facing any serialization program: ensuring the engagement and support of executive stakeholders in each of the many functional areas required to successfully implement a serialization strategy.