Pharmatek Laboratories, Inc. has added roller compaction to its solid oral dosage form manufacturing capabilities with the purchase of two roller compactors, a pilot-scale Vector TFC-220 roller compactor with a rate of 20 kg/hour, and a Vector TFC-LAB Micro lab-scale roller compactor with a rate of 1 kg/hour. Both machines have been integrated into the company’s GMP facility and are ready for manufacturing.

“The addition of roller compaction expands our granulation capability, especially in the area of moisture sensitive and density-challenged APIs. When used in conjunction with our microdose capsule filling technology (Xcelodose 600S and Symyx Powdernium MTM2005), roller compaction also provides an option for larger fill weights in powder-in-capsule dosage forms,” said Kevin Rosenthal, Pharmatek’s director of manufacturing. “Additionally, with the purchase of two roller compactors we now have dry granulation capability in our highly-potent and non-highly-potent manufacturing facilities.”

Pharmatek has also expanded single-batch blending size capabilities (up to 36kg), adding a three cu. ft. V-blender. The company also increased capsule and tablet production with the purchase of a Bosch GKF400 automated encapsulator with a rate of 23,000 capsules/hour and a Korsch PH-106 instrumented tablet press with rate of 32,400 tablets/hour.