Baxter International has formed an agreement to acquire two hemostat and sealant products from Mallinckrodt—Recothrom Thrombin topical (Recombinant), the first and only stand-alone recombinant thrombin, and Preveleak Surgical Sealant, which is used in vascular reconstruction. Baxter will pay approximately $153 million for both products.

“Uncontrolled intraoperative bleeding can lead to a wide variety of clinical and economic complications for patients and hospitals. As a leading provider of advanced hemostats and sealants, Baxter is focused on continually identifying solutions to help meet surgeons’ varying needs,” said Wil Boren, president of Baxter’s advanced surgery business. “We are excited about the addition of Recothrom to help surgeons address less severe intraoperative bleeding and Preveleak to complement Baxter’s existing portfolio of sealants for cardiovascular and other surgical specialties.”

Thrombin is a proven blood coagulation agent—used on its own or in combination with other hemostats—that has been estimated to be used in more than one million patients per year in the U.S. to help surgeons address intraoperative bleeding. Recothrom is a thrombin-based product indicated as an aid to hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible and control of bleeding by standard surgical techniques is ineffective or impractical in adults and pediatric populations greater than or equal to one month of age. As the only topical hemostat from recombinant DNA origin approved in the U.S. and Canada, Recothrom can be used in pediatric and adult patients with or without antibodies to bovine-derived thrombin.

The acquisition also includes Preveleak, a surgical sealant designed to seal suture holes formed during surgical repair of the circulatory system and to reinforce sutured connections between blood vessels. Preveleak augments Baxter’s portfolio of complementary hemostats, sealants and tissue products used in cardiovascular and other surgeries, offering surgeons additional clinically differentiated products to address patients’ varying needs. PREVELEAK is approved in the U.S. and EU.

Sales of the proposed acquired products totaled approximately $56 million in the twelve months preceding September 29, 2017.