Thermo Fisher Scientific Inc., has introduced the Thermo Scientific DynaSpin Single-Use Centrifuge system designed to provide an optimal single-use solution for large-scale cell culture harvesting. The DynaSpin system is design to improve and streamline harvesting for cell culture separation in single-use bioprocesses by reducing the number of depth filtration cartridges required to complete the harvest process. According to the company, the DynaSpin solution delivers equivalent or improved product yield compared to traditional harvest systems while enabling operational efficiency, cost savings and sustainable practices in the production of biologics.
 
By reducing the number of filters required for harvesting, this product offers upwards of six-fold reduction in material requirements, eliminating 70% of waste compared to traditional harvest systems.
 
“We developed the DynaSpin system with an eye on efficiently harvesting biologics at large-scale, such as from our 5,000-liter Thermo Scientific DynaDrive Bioreactor,” said Srini Paluri, vice president & general manager, Thermo Fisher Scientific’s bioproduction business. “It was critical that the solution also consider the environment while outperforming traditional harvest solutions and delivering consistent product yields to our customers. The DynaSpin technology meets these objectives and will help our customers provide greater accessibility of therapeutics and vaccines globally.”
 
The DynaSpin system offers scalability, rapid change over, reduced downtime and lower risk of contamination to the workflow, according to the company. The ergonomic design of the system provides ease of access for system operation and maintenance, including loading and unloading the single-use rotor and line set assembly. DynaSpin provides configurable user access, audit trail and batch reporting, allowing the users to meet 21 CFR Part 11 compliance.