Bespak, a contract development and manufacturing organization (CDMO) focused on orally inhaled and nasal drug-device combination products, has announced new collaborations with The Medicines Evaluation Unit (MEU) and H&T Presspart.
 
Both partnerships are aimed at accelerating the industry’s transition from existing pressurized Metered Dose Inhaler (pMDI) formulations to more climate-friendly alternatives utilizing low global warming potential (GWP) propellants.

Collaboration with The Medicines Evaluation Unit

Bespak’s partnership with The Medicines Evaluation Unit (MEU), one of the UK’s leading contract research organizations, will align expert teams from the two organizations who will share knowledge and combine resources in order to fast-track time to clinic, and increase the throughput of low GWP pMDIs moving through clinical evaluation.
 
Designed to service the increasing demand from pharmaceutical companies transitioning their inhaler portfolios to utilize the new generation of greener propellants, the collaboration will leverage Bespak’s clinical supply capabilities at its Holmes Chapel site to manufacture pMDIs containing the new propellants (HFA-152a and HFO-1234ze), for use in clinical studies to be conducted at the MEU. The collaboration also includes MEU’s Regulatory consultancy for clients to access as part of a package of services.
 
The companies will focus their activities with their teams working in close geographical proximity at their sites in the North West of England.

Collaboration with H&T Presspart

Meanwhile, Bespak and H&T Presspart, a leader in the development, manufacturing and supply of inhaled drug delivery components and devices, aim to bring rapid access to small-scale filling capabilities in GMP conditions to support development programs and clinical trials with both HFA-152a and HFO-1234ze propellants.
 
The collaboration leverages H&T Presspart’s expertise in inhalation product development, the company’s low GWP filling equipment and market-leading portfolio of componentry, and Bespak’s expertise and leading position in valves as well as its formulation development expertise and finished product manufacturing capability. The partnership will accelerate industry understanding and customer success in the reformulation and commercialization of products with a significantly lower environmental footprint.