AbbVie has completed its previously announced acquisition of Aliada Therapeutics, a biotechnology company developing therapies using a novel blood-brain barrier (BBB)-crossing technology for central nervous system (CNS) diseases. The transaction was valued at $1.4 billion.
 
Aliada’s lead investigational asset utilizing its delivery technology, ALIA-1758, is an anti-pyroglutamate amyloid beta (3pE-Aβ) antibody in development for the treatment of Alzheimer’s disease.
 
“Alzheimer’s disease poses a significant public health challenge, impacting millions worldwide and is becoming more prevalent as populations age,” said Dawn Carlson, M.D., M.P.H., vice president, neuroscience development at AbbVie. “With the acquisition now complete, we look forward to advancing potentially disease-modifying therapies such as ALIA-1758 for Alzheimer’s disease and bolstering our neuroscience discovery and development efforts by leveraging Aliada’s novel CNS drug delivery platform.”
 
“We are pleased to announce the acquisition of Aliada by AbbVie and are excited about AbbVie’s commitment to bringing ALIA-1758 to patients with Alzheimer’s disease. Our proprietary MODEL platform has enabled the development of ALIA-1758, a promising step forward in brain delivery of an anti-amyloid antibody therapy,” said Michael Ryan, M.D., chief medical officer at Aliada Therapeutics.

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