Amytrx Therapeutics has expanded their bioactive peptide platform beyond the original lead therapeutic molecule to include a multi-purpose drug delivery vehicle and imaging agent. In its recently completed Phase I/IIa clinical trial as part of an FDA-approved adaptive Phase I/II clinical protocol, AMTX-100 has shown potential in rapidly improving outcomes for patients with the inflammatory skin disorder, atopic dermatitis (AD). A Phase IIb in adult subjects with mild to moderate AD is planned to start in 3Q 2022. Preclinical studies conducted for AMTX-100 to date allow for additional skin indications to start as Phase II trials. Amytrx is targeting additional studies in adolescent mild to moderate AD, psoriasis, lupus, rosacea, acne, shingles, herpes, and re-epithelialization/healing after chemical peels.

The potential of AMTX-100 in human peptide therapeutics has been made possible in part due to Amytrx Therapeutics and AmbioPharm’s collaboration. “AmbioPharm has been an excellent collaborator providing high-quality peptides to advance our R&D research and clinical development,” said Matthew Gonda, president and CEO, Amytrx. “Their technical advice and commitment to supporting manufacturing excellence has been crucial to developing economical, large-scale processes of difficult to manufacture peptides.”

AmbioPharm, a CDMO providing cGMP peptide APIs, actively engages with innovative biopharmaceutical companies in developing first-in-class, best-in-class and/or breakthrough peptide technologies that utilize their manufacturing expertise and in-depth scientific resources in novel and conventional peptide chemistry.

Currently, Amytrx Therapeutics is looking to connect with pharmaceutical, biotechnology, university researchers, and foundations to partner its AMTX-100 compounds to advance new or complementary therapies for chronic diseases where excessive inflammation or metabolic imbalances play key causative roles.