Avid Bioservices, Inc. is expanding its biomanufacturing capabilities with the installation of two Thermo Scientific HyClone Single-Use Bioreactors (SUB) at its facility in Tustin, CA. These systems enhance the company’s cell culture production services. The purchase of the 1000 L SUB follows the successful evaluation of a 100 L SUB in the company’s process development labs.  
    
The HyClone bioreactors consist of a reusable stainless steel outer support container and SUB BioProcess Container (BPC) that integrates with existing bioreactor control systems, providing the advantages of single-use bioprocessing without having to install a new bioreactor system. The retrofit product replaces the stainless steel bioreactor vessel in existing bioreactor systems, making it a flexible and economic option to increase bioreactor capacity, according to the company.
   
The company plans to use the 100 L SUB to produce antibodies and recombinant proteins in multi-gram quantities for clients and will also support the scale-up work for the 1000 L S.U.B, which will be used to produce clinical material under cGMP conditions.

“The growing demand for our biomanufacturing services led us to assess a number of options for increasing our capacity while maintaining our high quality,” said Richard Richieri, senior vice president of bioprocess development and manufacturing at Avid Bioservices.  “The Thermo Scientific HyClone SUB disposable system provides a state-of-the-art cell culture production solution that is cost-effective and complements our existing bioreactor production suite.  Based on our positive evaluation of the 100 L system, we are pleased to proceed with the larger unit, making Avid the first company in southern California to install the 1000 L SUB system.”