Bosch Introduces Xelum Platform for OSD

Platform combines dosing, mixing, granulating, and tableting in a continuous process

By: Kristin Brooks

Managing Editor, Contract Pharma

Bosch Packaging Technology introduced the Xelum platform for the continuous production of oral solid dosage (OSD) forms. The platform combines dosing, mixing, granulating, and tableting in a continuous process.


 
In continuous manufacturing, the typically separated process steps of batch production take place automatically and without interruption in a compact unit. The Xelum platform offers the granulation technology developed by the Bosch subsidiary Hüttlin, which comprises a unimodal particle size distribution, as well as good flow and tableting properties of the granules, and high product yields.

When transferring processes developed in the laboratory to production, the continuous process of the Xelum platform provides either a direct transfer without scale-up from R&D to production or supports the development process with an integrated, automated DoE (design of experiments) function.

Also, all ongoing processes can be recorded inline with intelligent sensors, and the quality characteristics can be controlled at any stage of production. The design of the system aims to ensure that no complex measurement or control technology is required. Up to the final dosage form, all ingredients can be traced back with the controlled product flow through the system, according to the company.      

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