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To develop scalable cGMP production for malaria antigen
October 29, 2013
By: Tim Wright
Editor-in-Chief, Contract Pharma
Leidos Holdings has awarded Pfenex a subcontract to develop a scalable, cGMP-ready production process for large-scale production of the blood-stage malaria antigen Plasmodium falciparum reticulocyte-binding homolog 5 (Rh5). The contract follows successful preclinical studies performed by Leidos collaborators to evaluate the Rh5 antigen that was produced using the Pfēnex Expression Technology platform. The subcontract is funded with federal funds from Leidos’ prime Malaria Vaccine Production and Support Services (MVPSS) contract (N01.AI.05421) from the National Institute of Allergy and Infectious Diseases (NIAID). Pfenex will begin process development activities while continuing to provide materials to Leidos and NIAID for ongoing preclinical studies. “We are pleased to be awarded this contract as we expand our effort to find an effective therapy for malaria,” said Bertrand C. Liang, Pfenex’s chief executive officer. “Pfenex Expression Technology has once again demonstrated its ability to efficiently produce a high-value, complex protein enabling the potential of a multivalent malaria vaccine.” “Working with Pfenex and NIAID on this program is an important step in the development of an effective malaria vaccine,” said James Pannucci, Ph.D., vice president of the Leidos Health Life Sciences team. “We hope our work will lead to new discoveries and have a profound effect on the world’s health.” The Leidos Life Science team operates a virtual drug development enterprise that bridges the gap between federal agencies and commercial clients, along with a modest portfolio of vaccine and therapeutic candidates.
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