Explore recent issues of Contract Pharma covering key industry trends.
Read the full digital version of our magazine online.
Stay informed! Subscribe to Contract Pharma for industry news and analysis.
Get the latest updates and breaking news from the pharmaceutical and biopharmaceutical industry.
Discover the newest partnerships and collaborations within the pharma sector.
Keep track of key executive moves and promotions in the pharma and biopharma industry.
Updates on the latest clinical trials and regulatory filings.
Stay informed with the latest financial reports and updates in the pharma industry.
Expert Q&A sessions addressing crucial topics in the pharmaceutical and biopharmaceutical world.
In-depth articles and features covering critical industry developments.
Access exclusive industry insights, interviews, and in-depth analysis.
Insights and analysis from industry experts on current pharma issues.
A one-on-one video interview between our editorial teams and industry leaders.
Listen to expert discussions and interviews in pharma and biopharma.
A detailed look at the leading US players in the global pharmaceutical and BioPharmaceutical industry.
Browse companies involved in pharmaceutical manufacturing and services.
Comprehensive company profiles featuring overviews, key statistics, services, and contact details.
A comprehensive glossary of terms used in the pharmaceutical and biopharmaceutical industry.
Watch in-depth videos featuring industry insights and developments.
Download in-depth eBooks covering various aspects of the pharma industry.
Access detailed whitepapers offering analysis on industry topics.
View and download brochures from companies in the pharmaceutical sector.
Explore content sponsored by industry leaders, providing valuable insights.
Stay updated with the latest press releases from pharma and biopharma companies.
Explore top companies showcasing innovative pharma solutions.
Meet the leaders driving innovation and collaboration.
Engage with sessions and panels on pharma’s key trends.
Hear from experts shaping the pharmaceutical industry.
Join online webinars discussing critical industry topics and trends.
A comprehensive calendar of key industry events around the globe.
Live coverage and updates from major pharma and biopharma shows.
Find advertising opportunities to reach your target audience with Contract Pharma.
Review the editorial standards and guidelines for content published on our site.
Understand how Contract Pharma handles your personal data.
View the terms and conditions for using the Contract Pharma website.
What are you searching for?
Fixed-dose combination tablet seeks to address pain and opioid-related illness
August 8, 2014
By: Kristin Brooks
Managing Editor, Contract Pharma
Daiichi Sankyo and Charleston Laboratories, Inc., through its subsidiary LOCL Pharma, Inc., have entered into a strategic collaboration for the development and U.S. commercialization of Charleston’s hydrocodone combination products, including CL-108, being studied for the treatment of moderate to severe pain and the reduction of Opioid-Induced Nausea and Vomiting (OINV). CL-108 combines 12.5 mg of immediate-release promethazine with 7.5 mg of hydrocodone and 325 mg of acetaminophen. Charleston recently completed a Phase III trial studying the effects of CL-108, which demonstrated high statistical significance. Daiichi’s U.S. subsidiary will be the commercialization partner for CL-108 in the U.S. and Charleston will be responsible for manufacturing, and will receive the right to co-promote this and other hydrocodone products in the U.S. Charleston Laboratories will receive $200 million, in an upfront cash payment and a near-term milestones and as much as an additional $450 million in milestones for the filing and approval of its fixed-dose hydrocodone products. Charleston will also receive an escalating share of profits from the products. “We are proud to partner with Charleston Labs on this exciting and unique fixed-dose combination tablet, which will seek to simultaneously address severe pain and opioid-related nausea and vomiting to benefit patients,” said Dr. Mahmoud Ghazzi, MD, Ph.D., global head of development and executive vice president at Daiichi Sankyo Co. “From our inception, it has been our goal to identify an industry-leading partner that is patient-focused, with a shared appreciation for the importance of educating healthcare providers on the significant issue of Opioid-Induced Nausea and Vomiting,” said Ryan Baker, founder and chief operating officer of Charleston Labs. “Daiichi Sankyo has successfully commercialized several medicines in the U.S., and we feel they are the ideal strategic fit for Charleston’s lead asset, CL-108.”
Enter your account email.
A verification code was sent to your email, Enter the 6-digit code sent to your mail.
Didn't get the code? Check your spam folder or resend code
Set a new password for signing in and accessing your data.
Your Password has been Updated !