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Now one CDMO can provide solutions for a full range of particle size reduction solutions
September 28, 2015
By: Tim Wright
Editor-in-Chief, Contract Pharma
Xcelience and Powdersize have added the Netzsch Delta Vita media mills, a nanoparticle milling solution, to their arsenal of capabilities. For the first time the company says one CDMO can provide solutions for a full range of particle size reduction solutions, from milling and micronization through cGMP manufacturing and global clinical supplies packaging and logistics. Xcelience made a structured cash investment in Powdersize in July of this year, adding milling and micronization capabilities to its capabilities. The addition of the Delta Vita compliments Powdersize’s micronization capability as a primary enabling technology for improving solubility. It provides additional size reduction to nano-scale particles. The Delta Vita is used for wet grinding of batches ranging from 15mL to approximately 60L. This technology allows for ample milling energies (or tip speeds) to generate sub 1μm particles and stabilize them into a suitably formulated solution. “Most of our formulation projects are BCS class II and need solubilization improvement,” said Derek Hennecke, president and chief executive officer, Xcelience. “We bought into Powdersize and its micronization tools to provide the simplest and most applicable solution. Now with wet bead milling, we can go after the sub 1μm particle size. It is a rare tool and Xcelience is proud to continue to offer novel, useful solutions like this.” “With the market leading Netzsch Delta Vita media milling equipment, we can tackle some of the most problematic API insolubility problems out there,” said TJ Higley, vice president of business development, Powdersize. “Nano particles are a cutting edge formulation solution, and with this piece of equipment we can offer a scale-able and regulatory established pathway with the use of wet media milling.”
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