Irvine Scientific has launched BalanCD CHO Feed 4, a chemically-defined, animal component-free powder feed for large-scale bioproduction in a variety of high performing CHO cells. According to the company, when paired with BalanCD CHO Growth A in fed-batch culture systems,up to 20 million viable cells/mL, and antibody titer up to 6g/ L can be achieved.
 
Recent developments in cell line engineering have allowed for higher cell densities and productivity rates. In order to achieve their full production potential, these cell lines require nutrient-rich media. However, these feeds can be difficult to dissolve and require complicated time-consuming preparation protocols, according to the company.
 
BalanCD CHO Feed 4 is designed and formulated to prepare easily using a simplified hydration procedure that does not require pH adjustments. BalanCD CHO Feed 4 maintains pH stability in culture and is designed to support growth while minimizing the production of metabolites that adversely affect titer levels; according to the company, this results in process consistency, significantly higher protein production and protein quality.
 
“Surveys of large-scale culture media end-users identify time and effort required for mixing powdered media as a top concern. By applying our expertise at media development and formulation we are able to deliver a product that provides performance, flexibility and ease-of-use that facilitates a more robust process.” said Dr. Jessie H.-T. Ni, chief scientific officer of Irvine Scientific. “This new Feed is a significant addition to our BalanCD CHO platform that is designed to streamline the development and scale-up process to help our customers get to market faster.”