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Biogen to focus on novel therapies for neurology
May 3, 2016
By: Tim Wright
Editor-in-Chief, Contract Pharma
Biogen has unveiled plans to spin off its hemophilia business as an independent, publicly traded company. The new company will build upon the strength of current therapies for hemophilia A and B while Biogen will focus on therapies for neurology. “We expect that the new company will be a leader in discovering, developing, and commercializing innovative therapies for hemophilia, built on remarkable science and a deep understanding of how to continually improve treatment for patients,” said George Scangos, chief executive officer, Biogen. “Our expanding hemophilia business continues to perform very well. Eloctate and Alprolix provide meaningful benefits for people living with hemophilia and continue to gain market share. We believe that the best way to realize the full potential of this growing and vital business is to enable it to operate independently with a management team dedicated to providing therapies to people living with hemophilia. “For Biogen, our mission remains unchanged: we continue to aspire to have the greatest impact on patients of any biotechnology company in the history of our industry,” said Dr. Scangos. “Biogen is poised to make a tremendous difference in the lives of millions of people suffering from diseases with a neuronal etiology, including neurodegeneration, neuromuscular disorders, neuropathic pain, and ophthalmological indications. Our depth of knowledge in neuroscience and neurology is remarkable. The biological bases of many of these diseases are becoming clear, and we believe we are very well positioned to be a leader in these important areas. We will now carry out this mission through an even greater focus on therapies for patients with devastating neurodegenerative diseases for which there are few or no effective treatment options. And, we will accelerate our efforts to develop novel, transformative therapies for patients with MS, spinal muscular atrophy (SMA), Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and neuropathic pain.” The new company, to be named at a later date, will focus on the discovery and development of therapies for the treatment of hemophilia, with existing marketed products to include Eloctate and Alprolix, indicated for the treatment of hemophilia A and B, respectively. The new company is expected to continue to develop and commercialize Eloctate and Alprolix under Biogen’s existing collaboration agreement with Swedish Orphan Biovitrum AB (publ)(Sobi). Eloctate and Alprolix generated combined revenues of $640 million during the twelve-month period ended March 31, 2016. The new company plans to bring longer acting therapies utilizing the XTEN technology into clinical development in the first half of 2017 and to accelerate the development of bispecific antibodies and hemophilia-related gene therapy programs. The new company also plans to conduct additional studies to confirm early data that suggest Eloctate’s potential to rapidly induce immune tolerance in hemophilia patients who develop inhibitors. Biogen believes the spin-off of its hemophilia business—anchored by Eloctate and Alprolix—into a separate publicly traded company will result in two lean, profitable companies. John Cox, Biogen’s current executive vice president, pharmaceutical operations and technology, will serve as the chief executive officer of the new company. Mr. Cox joined Biogen in 2003 and has held several senior executive positions. The new company is expected to be headquartered in the Boston area. The new company will retain commercial rights for Eloctate and Alprolix for North America and for rest of the world markets outside of, essentially, Europe, North Africa, Russia and certain countries in the Middle East. Biogen is expected to provide transition services to the new company for some period of time and is expected to remain the manufacturer of Eloctate and Alprolix for the next three to five years. The full management team and board of directors of the new company will be named at a later date. The spin-off is planned to be completed by the end of 2016 or early 2017.
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