• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Manufacturing
    • Packaging
    • Development
    • Compliance
    • Top 20
    • Directory
    • Solution Center
    • Events
    • More
  • Magazine
  • News
  • Manufacturing
  • Packaging
  • Development
  • Compliance
  • Top 20
  • Directory
  • Solution Center
  • Events
  • Current / Back Issue
    Features
    Editorial
    Columns
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Subscribe Now
    Advertise Now
    Top Features
    CDMOs in the Spotlight: Investing in Themselves

    Extrusion-Spheronization in OSD Manufacturing

    Modernizing Therapeutic Cell Production

    Don’t Panic! A Toxicologist’s View on Proceeding After a Clinical Hold

    Digital Transformation in Pharma
    Breaking News
    Online Exclusives
    Industry News
    Collaborations & Alliances
    Promotions & Moves
    Trials & Filings
    Financial Reports
    Bio News & Views
    Custom Sourcing News
    Packaging & Tracking
    CRO News
    Live From Shows
    Top News
    ValiRx Signs Lease Deal with Nottingham Laboratories

    Civica Partners with Ypsomed for Insulin Injection Pen

    Charles River Laboratories Completes the Acquisition of SAMDI Tech

    Selkirk Pharma Names New Director for Business Development

    Center for Breakthrough Medicines Introduces Precision Plasmids Manufacturing
    APIs
    Aseptic Processing
    Cleaning Validation
    Clinical Trial Materials
    Cytotoxics and High Potency Manufacturing
    Equipment
    Excipients
    Extractables and Leachables
    Facilities
    Fill/Finish
    Lyophilization
    Parenterals
    Process Development
    Process Validation
    Risk Management
    Scale-up/ Technology Transfer
    Solid Dosage/ Creams/ Ointments

    Center for Breakthrough Medicines Introduces Precision Plasmids Manufacturing

    Upsher-Smith Opens State-of-the-Art Manufacturing Facility

    Elektrofi, Thermo Fisher Enter Strategic Contract Manufacturing Pact

    Societal CDMO Signs More Than $6M in Work Orders During 4Q22

    Genenta Science, AGC Biologics Enter Development and Manufacturing Service Pact
    Capsules
    Cold Chain Management
    Injectables
    Logistics
    Serialization
    Solid Dosage / Semi-solids
    Supply Chain
    Vials

    Upsher-Smith Opens State-of-the-Art Manufacturing Facility

    Beat the Supply Chain Backlog

    HPNE Launches Innovative Single-Use Assembly Service

    CDMO Selection and Tech Transfer – An Insider’s Guide to Injectables Excellence

    Catalent Bolsters Cell and Gene Services
    Analytical Services
    Bioanalytical Services
    Bioassay Developement
    Biologics, Proteins, Vaccines
    Biosimilars
    Chemistry
    Clinical Trials
    Drug Delivery
    Drug Development
    Drug Discovery
    Formulation Development
    Information Technology
    Laboratory Testing
    Methods Development
    Microbiology
    Preclinical Outsourcing
    R&D
    Toxicology

    ValiRx Signs Lease Deal with Nottingham Laboratories

    Center for Breakthrough Medicines Introduces Precision Plasmids Manufacturing

    Genenta Science, AGC Biologics Enter Development and Manufacturing Service Pact

    Baby Steps Toward the 21st Century

    Modernizing Therapeutic Cell Production
    Filtration & Purification
    GMPs/GCPs
    Inspections
    QA/QC
    Regulatory Affairs
    Validation

    Don’t Panic! A Toxicologist’s View on Proceeding After a Clinical Hold

    People and Culture Drive Operational Excellence

    Adare Partners with Veeva to Strengthen Quality Operations

    KBI Secures Swissmedic Regulatory Establishment License for Facility in Geneva

    Enhancing Ease of Use, Batch Turnaround, and Process Flexibility
    Companies
    Categories
    Corporate Capabilities
    Add New Company
    Contract Service Directory Companies
    Syngene International Ltd.

    INCOG BioPharma Services

    Alcami

    Societal CDMO

    Bachem
    Companies
    News Releases
    Posters
    Brochures
    Services
    Videos
    Case Study
    White Papers
    Jobs
    Contract Service Directory Companies
    Syngene International Ltd.

    INCOG BioPharma Services

    Alcami

    Societal CDMO

    Bachem
    Webinars
    Live From Shows
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
      • Enewsletter Archive
      • Digital Edition
    • Directory
      • Companies
      • Categories
      • Corporate Capabilities
      • Add Your Company
    • Manufacturing
      • APIs
      • Aseptic Processing
      • Cleaning Validation
      • Clinical Trial Materials
      • Cytotoxics and High Potency Manufacturing
      • Equipment
      • Excipients
      • Extractables and Leachables
      • Facilities
      • Fill/Finish
      • Lyophilization
      • Parenterals
      • Process Development
      • Process Validation
      • Risk Management
      • Scale-up/ Technology Transfer
      • Solid Dosage/ Creams/ Ointments
      • cGMP Manufacture
    • Packaging
      • Capsules
      • Cold Chain Management
      • Injectables
      • Logistics
      • Serialization
      • Solid Dosage / Semi-solids
      • Supply Chain
      • Vials
    • Development
      • Analytical Services
      • Bioanalytical Services
      • Bioassay Developement
      • Biologics, Proteins, Vaccines
      • Biosimilars
      • Chemistry
      • Clinical Trials
      • Drug Delivery
      • Drug Development
      • Drug Discovery
      • Formulation Development
      • Information Technology
      • Laboratory Testing
      • Methods Development
      • Microbiology
      • Preclinical Outsourcing
      • R&D
      • Toxicology
    • Compliance
      • Filtration & Purification
      • GMPs/GCPs
      • Inspections
      • QA/QC
      • Regulatory Affairs
      • Validation
    • Top 25 Pharma & BioPharma
    • Contract Pharma Direct
    • Breaking News
    • Online Exclusives
    • Slideshows
    • Experts Opinions
    • Surveys
      • Outsourcing Survey
      • Salary Survey
    • Glossary
    • Videos
    • White Papers
    • Podcasts
    • Infographics
    • Microsites
      • Companies
      • News Releases
      • Posters
      • Brochures
      • Services
      • Videos
      • Case Study
      • White Papers
    • Contract Pharma Conference
      • Contract Pharma Conference
      • Speakers
      • Exhibitors
      • Conference Sessions
    • eBook
    • Webinars
    • Events
      • Industry Events
      • Live from Show Events
      • Webinars
    • Classifieds / Job Bank
      • Classifieds
      • Job Bank
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    BMS, CytomX Expand Probody Pact

    BMS gains worldwide rights to develop and commercialize as many as six additional oncology targets

    Related Content
    • Eisai, BMS Enter Global Anticancer ADC Alliance
    • Top 25 Pharma and Biopharma Companies
    • Top 25 Pharma and Biopharma Companies
    • Top 25 Pharma and Biopharma Companies
    • Evotec Opens U.S. HQ in NJ
    03.20.17

    Bristol-Myers Squibb Company and CytomX Therapeutics, Inc., a biopharma company developing investigational Probody therapeutics to treat cancer, have expanded their 2014 strategic collaboration to discover therapies that will include as many as eight additional targets using CytomX’s Probody platform.

    Probody therapeutics are designed to leverage unique conditions in the tumor microenvironment to enhance tumor-targeting features of an antibody and reduce drug activity in healthy tissues. Probody therapeutics bind selectively to cells within tumor tissue with reduced binding to healthy tissue, potentially improving or creating a therapeutic window. These therapeutics may also have application in other diseases where proteases are dysregulated in affected tissues.

    Under the original collaboration, BMS selected four oncology targets, and to date, has progressed the CTLA-4 Probody therapeutic to Investigational New Drug-enabling studies and the three other programs are in the lead discovery and optimization phase.

    BMS will have exclusive worldwide rights to develop and commercialize Probody therapeutics for as many as six additional oncology targets and two non-oncology targets. CytomXwill receive an upfront payment of $200 million and research funding over the course of the research term. CytomX will also be eligible to receive as much as $448 million in future development, regulatory and sales milestones for each collaboration target, as well as royalties on sales.

    “CytomX’s Probody platform has enhanced our discovery research as we seek to direct the therapeutic effects of immunotherapy in a more targeted approach against tumors,” said Carl Decicco, Ph.D., head of Discovery, BMS. “We look forward to working more extensively with CytomX on this innovative and potentially disruptive approach in oncology as well as other disease areas.”

    “This expanded collaboration with Bristol-Myers Squibb gives CytomX the opportunity to further the reach of our potentially transformational Probody technology and provides us with additional financial and strategic flexibility to build our company,” said Sean McCarthy, D. Phil., president and chief executive officer of CytomX. “With CX-072 in Phase 1/2, and CX-2009 approaching clinical studies, our broad wholly-owned pipeline is poised for initial proof of concept as we aim to reinvent therapeutic antibodies.”

    Related Searches
    • orphan
    • bms
    • collaboration
    • pipeline
    Suggested For You
    Eisai, BMS Enter Global Anticancer ADC Alliance Eisai, BMS Enter Global Anticancer ADC Alliance
    Top 25 Pharma and Biopharma Companies Top 25 Pharma and Biopharma Companies
    Top 25 Pharma and Biopharma Companies Top 25 Pharma and Biopharma Companies
    Top 25 Pharma and Biopharma Companies Top 25 Pharma and Biopharma Companies
    Evotec Opens U.S. HQ in NJ Evotec Opens U.S. HQ in NJ
    INC Research, inVentiv Health to Merge INC Research, inVentiv Health to Merge
    Ligand Licenses Captisol-Enabled Ganaxolone Ligand Licenses Captisol-Enabled Ganaxolone
    Permira Funds Acquires LSNE Permira Funds Acquires LSNE
    BMS Names EVP, CSO BMS Names EVP, CSO
    BMS, GRAIL in Precision Medicine Pact BMS, GRAIL in Precision Medicine Pact
    Q Laboratories Names Chief Executive Q Laboratories Names Chief Executive
    Financial Report: Bristol-Myers Squibb Financial Report: Bristol-Myers Squibb
    Pharmaron Acquires Xceleron Pharmaron Acquires Xceleron
    Innate Achieves $15M BMS Milestone Innate Achieves $15M BMS Milestone
    Eurofins Acquires Villapharma in Spain Eurofins Acquires Villapharma in Spain

    Related Breaking News

    • Biologics, Proteins, Vaccines | Breaking News | Drug Development | Industry News
      Eisai, BMS Enter Global Anticancer ADC Alliance

      Eisai, BMS Enter Global Anticancer ADC Alliance

      BMS to pay as much as $2.45B to co-develop Eisai’s MORAb-202
      06.18.21

    • Top 25 Pharma and Biopharma Companies

      Top 25 Pharma and Biopharma Companies

      (Based on 2018 Pharma/Biopharma Sales, in $U.S. Millions)
      Tim Wright & Kristin Brooks 07.18.19

    • Top 25 Pharma and Biopharma Companies

      Top 25 Pharma and Biopharma Companies

      ...
      07.15.19


    • Top 25 Pharma and Biopharma Companies

      Top 25 Pharma and Biopharma Companies

      ...
      07.20.18

    • Breaking News | Drug Development | Drug Discovery | Facilities | Industry News
      Evotec Opens U.S. HQ in NJ

      Evotec Opens U.S. HQ in NJ

      Also unveils 20,000 square-foot facility expansion
      05.26.17

    Loading, Please Wait..
    Trending
    • Steriline Provides Fill-Finish Solution For Berkshire Sterile Manufacturing
    • Thermo Fisher, Celltrio Partner On Cell Line Automation Platform
    • Bristol Myers Squibb 4Q Results
    • Astellas Announces New President And CEO And Management Structure
    • Bionova Expansion Project To Quadruple GMP Biologics Manufacturing Capacity
    Breaking News
    • ValiRx Signs Lease Deal with Nottingham Laboratories
    • Civica Partners with Ypsomed for Insulin Injection Pen
    • Charles River Laboratories Completes the Acquisition of SAMDI Tech
    • Selkirk Pharma Names New Director for Business Development
    • Center for Breakthrough Medicines Introduces Precision Plasmids Manufacturing
    View Breaking News >
    CURRENT ISSUE

    January/February 2023

    • CDMOs in the Spotlight: Investing in Themselves
    • Extrusion-Spheronization in OSD Manufacturing
    • Modernizing Therapeutic Cell Production
    • Don’t Panic! A Toxicologist’s View on Proceeding After a Clinical Hold
    • Digital Transformation in Pharma
    • Fill-Finish in Cell & Gene Therapy
    • Early-Stage Biotechs: What’s Essential and What’s Not
    • Five Insights to Maximize Customer-Centric Acquisition Growth
    • Challenges in API Technical Transfer
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    ADM Expands Production to Meet Demand for Probiotics
    Wiley’s Finest Debuts Peak DHA Featuring 600 mg of DHA and 300 mg of EPA
    FDA to Allow Qualified CVD Risk Reduction Claim for Cocoa Flavanols in High Flavanol Cocoa Powder
    Coatings World

    Latest Breaking News From Coatings World

    Personnel Changes at BASF
    Dr. Kurt Wood to Deliver Mattiello Memorial Lecture at ACA’s 2023 CoatingsTech Conference
    hubergroup Chemicals to Debut at the European Coatings Show
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Konica Minolta Introduces Mobile X-Ray Systems to Latin America
    NIH MedTech Program Aims to Develop Neurological Treatment Tech
    Formula Plastics Appoints Bill Gerard as President
    Contract Pharma

    Latest Breaking News From Contract Pharma

    ValiRx Signs Lease Deal with Nottingham Laboratories
    Civica Partners with Ypsomed for Insulin Injection Pen
    Charles River Laboratories Completes the Acquisition of SAMDI Tech
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Tree Hut Introduces Body Wash Line
    Zara Introduces Mini Artists—Beauty Products for Kids
    L’Oréal USA Taps Stephanie Kramer as Chief Human Resources Officer
    Happi

    Latest Breaking News From Happi

    FTC Extends Public Comment Period on Potential Updates to Green Guides
    Arm & Hammer Taps Dave & Jenny Marrs, TikTokers for Budget-Centered 'Give It The Hammer' Campaign
    Meaningful Beauty Age-Proof Hair Care System Now Available on Amazon
    Ink World

    Latest Breaking News From Ink World

    Siegwerk, Wildplastic, TU-Hamburg Partner on Deinking
    Brilliant Group and Terra Firm Launch Partnership
    hubergroup Chemicals Debuts at the European Coatings Show
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    The Oldham Group names Doug McClure technical sales rep
    Siegwerk partnership aims to improve plastic waste recyclability
    CELAB-Europe launches new web hub for liner recyclers
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Hospeco Offers TaskBrand Prep-Paint-Finish Wiping System
    Toray to Expand PPS Production in Korea
    Masque Bar Launches Compostable Sheet Masks
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    OSSIO Introduces Non-Permanent Compression Staple
    Dennis Jones Joins Intelivation Technologies as Manufacturing VP
    Jury Convicts Chiropractor, Orthopedic Surgeon in $31M Fraud Scheme
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Nedap Follows NRF Success with Showcase at EuroShop 2023
    NXP Semiconductors Reports 4Q, Full-Year 2022 Results
    Zebra Technologies Extends Partnership with the NFL

    Copyright © 2023 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login