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Addition of ACAM2000, the only FDA-licensed smallpox vaccine, expands and diversifies portfolio of medical countermeasures
July 14, 2017
By: Tim Wright
Editor-in-Chief, Contract Pharma
Emergent BioSolutions has acquired the ACAM2000 business of Sanofi for $125 million. The upfront cost is $97.5 million with up to $27.5 million in near-term contingent regulatory and manufacturing-related milestones. ACAM2000 (Smallpox (Vaccinia) Vaccine, Live) is the only vaccine licensed by the U.S. FDA for active immunization against smallpox disease for persons determined to be at high risk for smallpox infection. Emergent also takes control of an existing 10-year contract originally valued at up to $425 million with the Centers for Disease Control and Prevention (CDC) with a remaining value of up to approximately $160 million for deliveries of ACAM2000 to the Strategic National Stockpile (SNS). The deal includes a cGMP bulk manufacturing facility and a lease to a cGMP fill/finish facility, both U.S.-based, along with the existing staff of approximately 100 employees. “This transaction diversifies our portfolio and broadens our countermeasure franchise with a vaccine that is being stockpiled both in the U.S. and internationally,” said Daniel Abdun-Nabi, president and chief executive officer, Emergent BioSolutions. “We expect it to meaningfully contribute to revenue growth in 2018 and advance our efforts towards achieving our goal of $1 billion in total revenue by 2020. We further anticipate that ACAM2000 will help us achieve our goal of generating more than 10% of total revenue from international markets. This acquisition fits squarely within our core strategy and business focus, and we look forward to closing this transaction and to integrating this business into our operations.” The addition of ACAM2000 expands the company’s portfolio of only-in-class products, diversifies its portfolio of medical countermeasures against Category A bioterrorism agents, and is synergistic with its existing smallpox countermeasure offering, specifically VIGIV [Vaccinia Immune Globulin Intravenous (Human)], the only FDA-licensed therapeutic for certain complications from smallpox vaccination. Emergent expects that this transaction will enhance its contract manufacturing operations through the addition of live viral manufacturing and fill/finish capabilities and the execution of a contract manufacturing agreement to supply bulk drug substance for one of Sanofi’s commercial vaccines.
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