• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Manufacturing
    • Packaging
    • Development
    • Compliance
    • Top 25
    • Directory
    • Microsites
    • Events
    • More
  • Magazine
  • News
  • Manufacturing
  • Packaging
  • Development
  • Compliance
  • Top 25
  • Directory
  • Microsites
  • Events
  • Current / Back Issue
    Features
    Editorial
    Columns
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Subscribe Now
    Advertise Now
    Top Features
    Bye-Bye China?

    Decentralized Trials Fuel AI Revolution in Clinical Research

    Self-Medication: Flexibility for Patients and Drug Manufacturers

    The Single-Use Mixing Landscape: Evaluating Your Options

    DCAT President Talks COVID-19, Drug Manufacturing and Innovation
    Breaking News
    Online Exclusives
    Industry News
    Collaborations & Alliances
    Promotions & Moves
    Trials & Filings
    Financial Reports
    Bio News & Views
    Custom Sourcing News
    Packaging & Tracking
    CRO News
    Live From Shows
    Top News
    Civica to Build an Essential Medicines Manufacturing Facility in Virginia

    Humanigen, Emergent Enter Covid-19 Partnership

    Samsung Bioepis Opens New Headquarters

    Pfizer, BioNTech Enter Vax Pact with COVAX

    FDA Approves Janssen’s CABENUVA
    APIs
    Aseptic Processing
    Cleaning Validation
    Clinical Trial Materials
    Cytotoxics and High Potency Manufacturing
    Equipment
    Excipients
    Extractables and Leachables
    Facilities
    Fill/Finish
    Lyophilization
    Parenterals
    Process Development
    Process Validation
    Risk Management
    Scale-up/ Technology Transfer
    Solid Dosage/ Creams/ Ointments

    Civica to Build an Essential Medicines Manufacturing Facility in Virginia

    Humanigen, Emergent Enter Covid-19 Partnership

    Samsung Bioepis Opens New Headquarters

    Integrated Continuous Manufacturing ICM

    CONTINUUS Awarded $69.3M DoD Grant
    Capsules
    Cold Chain Management
    Injectables
    Logistics
    Serialization
    Solid Dosage / Semi-solids
    Supply Chain
    Vials

    Civica to Build an Essential Medicines Manufacturing Facility in Virginia

    WDSrx Expands Warehouse Network

    Catalent Acquires Acorda’s INBRIJA Manufacturing Operations

    Varcode, PL Developments Form Strategic ‘Smart Tag’ Pact

    COVID-19 Vaccine Distribution: The Air Cargo Industry’s Greatest Challenge
    Analytical Services
    Bioanalytical Services
    Bioassay Developement
    Biologics, Proteins, Vaccines
    Biosimilars
    Chemistry
    Clinical Trials
    Drug Delivery
    Drug Development
    Drug Discovery
    Formulation Development
    Information Technology
    Laboratory Testing
    Methods Development
    Microbiology
    Preclinical Outsourcing
    R&D
    Toxicology

    Humanigen, Emergent Enter Covid-19 Partnership

    Samsung Bioepis Opens New Headquarters

    Lilly Completes $1B Acquisition of Prevail

    Top BioPharma Form Accumulus Synergy

    Coating Place Wurster Fluid Bed Process Scaling
    Filtration & Purification
    GMPs/GCPs
    Inspections
    QA/QC
    Regulatory Affairs
    Validation

    Top BioPharma Form Accumulus Synergy

    Global Biosciences Co. Selects ValGenesis VLMS

    Gene Therapy Co. Selects ValGenesis' SaaS Platform

    The Year of COVID: How FDA Coped with a Worldwide Pandemic in 2020 and What to Expect in 2021

    Samsung Biologics Adopts Veeva Vault QMS to Unify Quality Management
    Companies
    Categories
    Corporate Capabilities
    Add New Company
    Contract Service Directory Companies
    Reed-Lane

    Baxter BioPharma Solutions

    Almac Group

    Alcami

    PCI Pharma Services
    Companies
    News Releases
    Posters
    Brochures
    Services
    Videos
    Case Study
    White Papers
    Jobs
    Contract Service Directory Companies
    PCI Pharma Services

    Almac Group

    Reed-Lane

    Aphena Pharma Solutions

    Emergent BioSolutions
    Webinars
    Live From Shows
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
      • Enewsletter Archive
      • Digital Edition
    • Directory
      • Companies
      • Categories
      • Corporate Capabilities
      • Add Your Company
    • Manufacturing
      • APIs
      • Aseptic Processing
      • Cleaning Validation
      • Clinical Trial Materials
      • Cytotoxics and High Potency Manufacturing
      • Equipment
      • Excipients
      • Extractables and Leachables
      • Facilities
      • Fill/Finish
      • Lyophilization
      • Parenterals
      • Process Development
      • Process Validation
      • Risk Management
      • Scale-up/ Technology Transfer
      • Solid Dosage/ Creams/ Ointments
      • cGMP Manufacture
    • Packaging
      • Capsules
      • Cold Chain Management
      • Injectables
      • Logistics
      • Serialization
      • Solid Dosage / Semi-solids
      • Supply Chain
      • Vials
    • Development
      • Analytical Services
      • Bioanalytical Services
      • Bioassay Developement
      • Biologics, Proteins, Vaccines
      • Biosimilars
      • Chemistry
      • Clinical Trials
      • Drug Delivery
      • Drug Development
      • Drug Discovery
      • Formulation Development
      • Information Technology
      • Laboratory Testing
      • Methods Development
      • Microbiology
      • Preclinical Outsourcing
      • R&D
      • Toxicology
    • Compliance
      • Filtration & Purification
      • GMPs/GCPs
      • Inspections
      • QA/QC
      • Regulatory Affairs
      • Validation
    • Top 25 Pharma & BioPharma
    • Contract Pharma Direct
    • Breaking News
    • Online Exclusives
    • Slideshows
    • Experts Opinions
    • Surveys
      • Outsourcing Survey
      • Salary Survey
    • Glossary
    • Videos
    • Podcasts
    • White Papers
    • Infographics
    • Contract Pharma Conference
      • Contract Pharma Conference
      • Speakers
      • Exhibitors
      • Conference Sessions
    • Supplier Microsite
      • Companies
      • News Releases
      • Posters
      • Brochures
      • Services
      • Videos
      • Case Study
      • White Papers
    • eBook
    • Webinars
    • Events
      • Industry Events
      • Live from Show Events
      • Webinars
    • Classifieds / Job Bank
      • Classifieds
      • Job Bank
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Aileron, Pfizer in Clinical Collaboration

    To evaluate the combination of Aileron’s ALRN-6924 and Pfizer’s IBRANCE in cancer

    Related CONTENT
    • Pfizer, BioNTech Enter Vax Pact with COVAX
    • The Year of COVID: How FDA Coped with a Worldwide Pandemic in 2020 and What to Expect in 2021
    • Natoli Engineering Appoints Northeast Service Technician
    • COVID-19 Vaccine Distribution: The Air Cargo Industry’s Greatest Challenge
    • Health Canada Authorizes Pfizer, BioNTech COVID-19 Vax
    11.27.18
    Aileron Therapeutics has entered into a clinical collaboration with Pfizer to evaluate the combination of Aileron’s ALRN-6924 and Pfizer’s palbociclib, also known as IBRANCE, in MDM2-amplified cancers. Overexpression of MDM2 in cancer is typically a driver of tumor proliferation. Aileron expects to start enrolling patients with solid tumors in the Phase IB trial in 1Q19. Pfizer will provide drug supply in support of the trial. 

    ALRN-6924 is a first-in-class, stabilized cell-permeating peptide that mimics the p53 tumor suppressor protein to disrupt the interaction with both its endogenous inhibitors, MDMX and MDM2. For p53 wild-type tumors, ALRN-6924 can restore p53-dependent tumor suppression.  Palbociclib is an oral inhibitor of cell cycle check-point regulators CDK4/6.  

    “We are excited about this combination trial with Pfizer’s palbociclib,” stated Manuel Aivado, MD, PhD, President and Chief Executive Officer of Aileron. “The combination of ALRN-6924 and palbociclib demonstrated enhanced antitumor activity and meaningfully delayed tumor growth in animal models over single agents alone. We believe the combination of these two drugs represents a complementary attack on the proliferation of cancer cells that may benefit patients with a variety of different cancers.”
    Related Searches
    • cancer
    • chief executive officer
    • collaboration
    • patients
    Suggested For You
    The State of Clinical Trial Technology The State of Clinical Trial Technology
    Pfizer, BioNTech Enter Vax Pact with COVAX  Pfizer, BioNTech Enter Vax Pact with COVAX
    The Year of COVID: How FDA Coped with a Worldwide Pandemic in 2020 and What to Expect in 2021 The Year of COVID: How FDA Coped with a Worldwide Pandemic in 2020 and What to Expect in 2021
    Natoli Engineering Appoints Northeast Service Technician Natoli Engineering Appoints Northeast Service Technician
    COVID-19 Vaccine Distribution: The Air Cargo Industry’s Greatest Challenge COVID-19 Vaccine Distribution: The Air Cargo Industry’s Greatest Challenge
    Health Canada Authorizes Pfizer, BioNTech COVID-19 Vax Health Canada Authorizes Pfizer, BioNTech COVID-19 Vax
    Health Canada Green Lights COVID-19 Vax Health Canada Green Lights COVID-19 Vax
    Frontida BioPharm Appoints Chief Financial Officer Frontida BioPharm Appoints Chief Financial Officer
    Pfizer, BioNTech Win First Authorization for COVID-19 Vax Pfizer, BioNTech Win First Authorization for COVID-19 Vax
    NeuBase Therapeutics Appoints Chief Scientific Officer NeuBase Therapeutics Appoints Chief Scientific Officer
    Pfizer, BioNTech Submit CMA for Covid-19 Vax to EMA Pfizer, BioNTech Submit CMA for Covid-19 Vax to EMA
    Life Science Success Podcast: Matt Hicks Life Science Success Podcast: Matt Hicks
    Pfizer and BioNTech to Submit EUA for COVID-19 Vaccine Pfizer and BioNTech to Submit EUA for COVID-19 Vaccine
    Delpharm to Manufacture Pfizer/BioNTech mRNA Vax in France Delpharm to Manufacture Pfizer/BioNTech mRNA Vax in France
    Pfizer, BioNTech Conclude Phase III COVID-19 Vax Study Pfizer, BioNTech Conclude Phase III COVID-19 Vax Study

    Related Breaking News

    • Bio News | Breaking News | Clinical Trial Materials | Clinical Trials | Collaborations & Alliances | Industry News
      Humanigen, Emergent Enter Covid-19 Partnership

      Humanigen, Emergent Enter Covid-19 Partnership

      Sign contract development and manufacturing agreement for Phase 3 COVID-19 therapeutic candidate lenzilumab.
      Tim Wright, Editor, Contract Pharma 01.25.21

    • Breaking News | Drug Development | Drug Discovery | Industry News
      Lilly Completes $1B Acquisition of Prevail

      Lilly Completes $1B Acquisition of Prevail

      Adds new modality for drug discovery and development and creates a gene therapy program with neuroscience assets.
      Kristin Brooks 01.22.21

    • Breaking News | Drug Development | Industry News | Information Technology | Regulatory Affairs
      Top BioPharma Form Accumulus Synergy

      Top BioPharma Form Accumulus Synergy

      Aims to develop a cloud-based Global Data Sharing Platform to facilitate data and information sharing between industry and health authorities worldwide.
      Kristin Brooks 01.22.21


    • Biologics, Proteins, Vaccines | Breaking News | Drug Development | Industry News
      AbbVie Licenses ProBioGen’s GlymaxX Technology

      AbbVie Licenses ProBioGen’s GlymaxX Technology

      Will apply GlymaxX technology to boost the antibody-dependent cell-mediated cytotoxicity (ADCC).
      Kristin Brooks 01.22.21

    • Bio News | Biologics, Proteins, Vaccines | Breaking News | Clinical Trials | Collaborations & Alliances | Industry News
      Intravacc Completes Project for Provention Bio’s Vax Candidate

      Intravacc Completes Project for Provention Bio’s Vax Candidate

      Potentially the first preventive vaccine for coxsackievirus B, a risk factor associated with type 1 diabetes and celiac disease.
      Contract Pharma Staff 01.19.21

    • Breaking News | Clinical Trials | Industry News
      Grifols Begins COVID-19 Plasma Treatment Trial

      Grifols Begins COVID-19 Plasma Treatment Trial

      Treatment could be used for people who test positive for COVID-19, avoiding hospitalization due to the progression of the disease, complementing the vaccine.
      Contract Pharma Staff 01.18.21


    • Breaking News | Collaborations & Alliances | Drug Development | Drug Discovery
      Janssen, TenNor Enter NTM Research Pact

      Janssen, TenNor Enter NTM Research Pact

      To leverage TenNor’s multitargeting drug conjugation platform to discover new therapies to treat nontuberculous mycobacteria diseases.
      Contract Pharma Staff 01.18.21

    • Breaking News | Clinical Trials | CRO News | Industry News
      Frontage Bolsters Clinical Services Capabilities

      Frontage Bolsters Clinical Services Capabilities

      Unveils plans to provide full service human radiolabeled absorption, metabolism, and excretion study capabilities.
      Contract Pharma Staff 01.15.21

    • Breaking News | Collaborations & Alliances | Drug Development | Drug Discovery | Industry News
      EVOQ Therapeutics and Amgen Partner

      EVOQ Therapeutics and Amgen Partner

      Collaborate on the discovery and development of novel drugs for autoimmune disorders.
      Contract Pharma Staff 01.13.21


    • Biologics, Proteins, Vaccines | Breaking News | Collaborations & Alliances | Drug Development
      Adagene Achieves CAR-T Collaboration Milestone

      Adagene Achieves CAR-T Collaboration Milestone

      Yields potential first-ever antibodies targeting human endogenous retrovirus associated with kidney cancer.
      Contract Pharma Staff 01.12.21

    • Breaking News | Clinical Trials | CRO News
      Parexel Completes Strategic Separation

      Parexel Completes Strategic Separation

      Aims to simplify and streamline business strategy and customer relationships while positioning both organizations for long-term growth.
      Contract Pharma Staff 01.12.21

    • Bio News | Breaking News | Collaborations & Alliances | Drug Development | Industry News
      Cyclolab and EpiPharma Form Joint Venture

      Cyclolab and EpiPharma Form Joint Venture

      Will develop and commercialize Peptide drug candidates for the treatment of debilitating CNS and Pulmonary diseases.
      Contract Pharma Staff 01.11.21


    • Clinical Trials | CRO News
      Caprion-HistoGeneX Acquires Clinical Logistics

      Caprion-HistoGeneX Acquires Clinical Logistics

      Expands its support of clinical trials specimen logistics.
      Contract Pharma Staff 01.08.21

    • Biologics, Proteins, Vaccines | Breaking News | Drug Development | Industry News | Laboratory Testing
      Biohaven Acquires Remaining Stake in Kleo Pharmaceuticals

      Biohaven Acquires Remaining Stake in Kleo Pharmaceuticals

      Enters exclusive license agreement with Yale University for a novel extracellular degrader technology licensed from Spiegel Lab.
      Contract Pharma Staff 01.08.21

    • Breaking News | Clinical Trials | Promotions & Moves
      Parexel Appoints Chief Patient Officer

      Parexel Appoints Chief Patient Officer

      Demonstrates the company’s commitment to elevating the patient perspective.
      Contract Pharma Staff 01.06.21

    Trending
    • Integrated Continuous Manufacturing ICM
    • Humanigen, Emergent Enter Covid-19 Partnership
    • Samsung Bioepis Opens New Headquarters
    • CDMO Northway Biotech Expands In U.S.
    • CONTINUUS Awarded $69.3M DoD Grant
    Breaking News
    • Civica to Build an Essential Medicines Manufacturing Facility in Virginia
    • Humanigen, Emergent Enter Covid-19 Partnership
    • Samsung Bioepis Opens New Headquarters
    • Pfizer, BioNTech Enter Vax Pact with COVAX
    • FDA Approves Janssen’s CABENUVA
    View Breaking News >
    CURRENT ISSUE

    November/December 2020

    • Modeling Process Safety Workflows in Pharmaceutical Manufacturing Scale-Up
    • Ensuring Quality During the Transfer and Scale Up of Rx Drugs
    • Inspecting the Unexpected
    • Cold Chain Trends
    • Catering for the Complex
    • Biopharma Contract Manufacturing: Robust Growth Ahead
    • DCAT President Talks COVID-19, Drug Manufacturing and Innovation
    • The Single-Use Mixing Landscape: Evaluating Your Options
    • Self-Medication: Flexibility for Patients and Drug Manufacturers
    • Decentralized Trials Fuel AI Revolution in Clinical Research
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Clinical Evidence Suggests Potential Oral Benefits for Curcumin Extract
    Oleic Acid Possibly Implicated in MS Pathology
    NIH Study Compares Low-Fat, Plant-Based to Low-Carb, Animal-Based Diet
    Coatings World

    Latest Breaking News From Coatings World

    APV Engineered Coatings Reflects on 2020
    LINE-X Launches Dealer Program with International Truck
    BCF CEO to Chair Royal Society of Chemistry Surface Coatings Interest Group
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Alleviant's Transcatheter Tech Obtains Breakthrough Status
    Signia Appoints New President
    At-Home COVID-19 Test Kits Boosts Disease Monitoring Capabilities
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Civica to Build an Essential Medicines Manufacturing Facility in Virginia
    Humanigen, Emergent Enter Covid-19 Partnership
    Samsung Bioepis Opens New Headquarters
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Fitglow Beauty Wins Big at Annual Dirty Thinker’s Choice Awards
    e.l.f. Cosmetics Unveils Mint Melt Collection
    Estée Lauder Companies Updates Supply Chain Leadership
    Happi

    Latest Breaking News From Happi

    Some Good News at Inter Parfums
    Professional Beauty Association Names New Executive Director
    Curcumin's Role in Oral Care
    Ink World

    Latest Breaking News From Ink World

    Paragon Expands Direct Mail Capabilities with Ricoh Pro VC70000
    BOBST Demonstrates Future of Flexible Packaging Production at Virtual Open House
    Morancé Soudure France Adds Comexi F2 MC 10-color Flexo Press
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    VPF launches deep-freeze adhesive
    ProMach strengthens flexible packaging business
    Gallus planning virtual event for March
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Kimberly-Clark Releases Q4, Full Year Results
    Freudenberg to Establish Apparel Interlining Competence Centers
    Minet Adds Spunlace Line in Romania
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    First Patient Implanted With NEXXT MATRIXX SA Cervical Turn-Lock System
    Cretex Companies CEO Steps Down
    Conformis Enters Development & Supply Agreement with SITES Medical
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    First Solar Signs Definitive Agreement to Sell US Development Platform to Leeward
    Imec Technology Taking Off to Space
    North American Semiconductor Equipment Industry Posts December 2020 Billings

    Copyright © 2021 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login