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    Breaking News

    Vectura and Monash University Support Development of Inhaled Oxytocin

    Aim to prevent postpartum hemorrhage in childbirth.

    Vectura and Monash University Support Development of Inhaled Oxytocin
    Inhaled oxytocin delivered via a dry powder inhaler would make child birth safer for mothers everywhere.
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    Contract Pharma Staff09.14.20
    Vectura Group plc has signed an agreement with Monash University’s Institute of Pharmaceutical Sciences (MIPS), to develop inhaled oxytocin delivered via a dry powder inhaler to prevent postpartum hemorrhage (PPH) in childbirth. An inhaled formulation of oxytocin, currently administered via injection, is expected to provide important advantages including ease of use, rapid onset of action and safe storage outside of the cold chain. Vectura will receive undisclosed revenues on a fee-for-service basis.
     
    Leveraging 20 years of experience in the formulation of inhaled products, Vectura will work with MIPS to optimize the product and advance to commercialization. Vectura will support the development of a single use device/formulation combination for evaluation in Phase I, and then expedite technical transfer to a commercial manufacturer to advance to Phase III and commercial launch.
     
    Will Downie, CEO of Vectura, commented, “Reformulation of oxytocin to an inhaled dry powder has many advantages for this drug and application. It will be easy to administer for patients, and, being inhaled, will have a rapid onset of action. Working with Monash University and its partners, we look forward to providing Vectura’s deep expertise in this space to address this important global health issue, potentially preventing thousands of deaths each year.”
     
    The World Health Organization (WHO) recommends that oxytocin is administered to every woman after birth to prevent PPH, and currently the only option for administration is via injection. The WHO suggests that there are approximately 60,000 deaths each year due to PPH, with more than 99% of these occurring in the poorest and hottest countries in the world, where injections are impracticable due to a lack of cold chain distribution, and safe, sterile environments, as well as trained clinicians to administer the drug.
     
    Professor Michelle McIntosh, project lead at MIPS, commented, “Post-partum hemorrhage is a significant and challenging global health issue so we are very excited to be working with Vectura on alow cost, heat stable and non-invasive approach to deliver oxytocin, overcoming existing limitations of current injection products.”
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