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    Breaking News

    Lonza Expands Solid Small Molecule Services

    To encompass all aspects of solid form screening and characterization of small molecule APIs.

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    Kristin Brooks02.16.21
    Lonza has expanded its solid form selection services based at its Bend, OR site. The added capabilities build on the SimpliFiH Solutions first-in-human services consisting of phase-appropriate drug substance and drug product development and manufacture. The solid form services offering also enhances Lonza’s capabilities to meet accelerated timelines for increasingly complex molecules.
     
    The selection of a lead solid involves the screening and characterization of both chemical forms (salts, cocrystals, solvates) and the associated polymorphs. The molecule's physicochemical properties and the target product profile dictate the need for screening salts, cocrystals, or bioavailability-enhanced formulations, and the key properties of any solid form: solubility, dissolution rate, manufacturability, stability, etc. Effective screening and selection are critical for early-stage and late-stage development to further process risk reduction and/or strengthen intellectual property claims.
     
    Lonza’s solid form services include form and salt/cocrystal screening, solid state characterization, chemical composition, solubility and dissolution, and powder properties.
     
    Christian Dowdeswell, VP and Global Head, Commercial Development – Small Molecules, said, “We continue to expand and refine our first-in-human services based on what our customers are telling us.  Choosing the right solid form and identifying the interplay between solid form and drug product is critical in the rapid advancement of molecules while minimizing risk and cost.  Our expanded solid form services offering is designed to meet the early stage molecule development of small biopharma players.”
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