Aptamer Group, the developer of Optimer reagents and therapeutics, has extended their current agreement with AstraZeneca. This agreement will build upon the existing collaboration to evaluate the potential of using Optimer-based strategies to target renal cells and explore the feasibility of developing next-generation drug delivery vehicles, Optimer-drug conjugates.  

Optimers are optimized aptamer reagents. Based on oligonucleotide molecules Optimers can bind specifically to a target molecule to act as an antibody alternative. Their ability to fold into distinct secondary or tertiary structures gives them high affinity and specific binding toward cell-specific targets. They are emerging as promising alternatives in a range of applications.

This extension will further unite Aptamer Group’s expertise and knowledge in the development of aptamer-based technologies with AstraZeneca’s leadership in Cardiovascular, Renal and Metabolism (CVRM) therapy development.
“We are really pleased to continue the collaboration with AstraZeneca,” said Arron Tolley, chief executive officer, Aptamer Group. “We believe that our platform technology could be transformational in the development of drug delivery vehicles. Through working with AstraZeneca, we can explore the potential of these new modalities in the early-stage drug development process."

Regina Fritsche Danielson, senior vice president and head of research and early development, cardiovascular, renal and metabolism, biopharmaceuticals R&D, AstraZeneca, said, “Oligonucleotide conjugates offer the potential to reach a specific cell or tissue, and have the potential to have a real impact for new drug targets identified in renal disease. By working together with Aptamer Group and leveraging their Optimer-based strategies we aim to identify novel targeting aptamers to deliver drug molecules to the kidney.”