PharmaLogic Holdings Corp., a contract development and manufacturing organization (CDMO) and radiopharmaceutical manufacturer, entered into a master services agreement with Viewpoint Molecular Targeting, Inc., a wholly owned subsidiary of Perspective Therapeutics, Inc., for the development and production of theranostic candidates VMT-01 and VMT-α-NET.

The radiopharmaceuticals are currently in development for the diagnosis and treatment of metastatic melanoma and neuroendocrine tumors (NETs), respectively.

PharmaLogic will produce and supply doses of VMT-01 and VMT-α-NET for use in Perspective’s early-stage clinical trials. This will complement the existing radiopharmaceutical GMP capability that Perspective already has at its mid-west site. 

Scott Holbrook, PharmaLogic’s chief strategy officer and general manager, said: “Targeted alpha therapy (TAT) with Pb-212 labeled radioligands offers one of the most exciting platforms for novel cancer therapy within the rapidly expanding precision radiotherapy ecosystem. The expertise of Perspective Therapeutics and PharmaLogic are well aligned to yield a successful collaboration around VMT-01 and VMT-α-NET.”

“We are delighted to select PharmaLogic as a trusted CDMO partner at this important juncture of the Viewpoint’s clinical development journey,” said Thijs Spoor, Perspective Therapeutics’ CEO. “Radiopharmaceutical diagnostic imaging and therapeutic agents have a limited shelf life from time of manufacture to patient administration in the clinical setting. PharmaLogic’s domain expertise in radiopharmaceuticals and broad national distribution footprint helps address our need for specialty radiopharmaceutical manufacturing at the highest level. As we have been given the safe to proceed authorizations from the U.S. Food and Drug Administration (FDA), we look forward to commencing enrollment of the company’s two image guided alpha-particle therapy studies at multiple clinical trial centers around the country.”

Chris Parr, PharmaLogic’s vice president of radiochemistry and technical operations said: “PharmaLogic is excited to partner with Perspective Therapeutics on the production and distribution of these personalized alpha-particle theranostics. We value Perspective’s scientific leadership in this area and believe it aligns perfectly with our mission of delivering clinically relevant precision medicine products to patients in the communities we serve.”