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    High Containment & Cost Savings with Single Use Isolator Technology

    The trend towards HPAPIs is driving the need for innovative containment systems.

    High Containment & Cost Savings with Single Use Isolator Technology
    A typical single use isolator for weigh and dispense. Courtesy of ILC Dover
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    Scott Patterson, Vice President Commercial Sales, ILC Dover01.31.19
    The current trend of increased potency of drug substances is driving the need for better cleaning methods to reduce cross contamination. The Level of Detection (LOD) methods are improving so that cleaning limits can be reduced to further mitigate risk of cross contamination due to retention on the process equipment and containment devices. Cleaning protocols are becoming more complicated to achieve the cleaning limit. In the case of isolator technology, the isolator surfaces add to the overall cleaning requirements while often making the cleaning ergonomically challenging. This is where a single use isolator will provide significant economic advantages, lower costs, and reduce the risks of cross- contamination over traditional hard wall isolators.
     
    Containment performance must be achieved
     
    The pharmaceutical market has been adopting single use or disposable solutions for over 20 years and the rate of installations continues to grow. The key issue has been containment performance and meeting the exposure limits of the highly potent active pharmaceutical ingredient market (HPAPI) market.

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