• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Manufacturing
    • Packaging
    • Development
    • Compliance
    • Top 25
    • Directory
    • Microsites
    • Events
    • More
  • Magazine
  • News
  • Manufacturing
  • Packaging
  • Development
  • Compliance
  • Top 25
  • Directory
  • Microsites
  • Events
  • Current / Back Issue
    Features
    Editorial
    Columns
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Subscribe Now
    Advertise Now
    Top Features
    Hygienic Packaging Technology

    Trends in Solid Oral Dosage Delivery

    5 Reasons Paper Has No Place in Contract Manufacturing

    Injectable Drug Delivery Trends

    Pharmaceutical Manufacturing Equipment Trends
    Breaking News
    Online Exclusives
    Industry News
    Collaborations & Alliances
    Promotions & Moves
    Trials & Filings
    Financial Reports
    Bio News & Views
    Custom Sourcing News
    Packaging & Tracking
    CRO News
    Live From Shows
    Top News
    AGC Biologics Expands Cell and Gene Facility in Italy

    Celonic to Boost Cell & Gene Therapy Production

    Pharmaron Acquires Biomanufacturing Site in the UK from AbbVie

    Aptamer Extends Collaboration with AstraZeneca

    Fujifilm Breaks Ground on Major Expansion of Biologics Facility in Denmark
    APIs
    Aseptic Processing
    Cleaning Validation
    Clinical Trial Materials
    Cytotoxics and High Potency Manufacturing
    Equipment
    Excipients
    Extractables and Leachables
    Facilities
    Fill/Finish
    Lyophilization
    Parenterals
    Process Development
    Process Validation
    Risk Management
    Scale-up/ Technology Transfer
    Solid Dosage/ Creams/ Ointments

    AGC Biologics Expands Cell and Gene Facility in Italy

    Celonic to Boost Cell & Gene Therapy Production

    Pharmaron Acquires Biomanufacturing Site in the UK from AbbVie

    Fujifilm Breaks Ground on Major Expansion of Biologics Facility in Denmark

    Reed-Lane Facility Virtual Tour
    Capsules
    Cold Chain Management
    Injectables
    Logistics
    Serialization
    Solid Dosage / Semi-solids
    Supply Chain
    Vials

    Reed-Lane Facility Virtual Tour

    Hygienic Packaging Technology

    Reshaping the Pharmaceutical Supply Chain

    Serialization: Level 5 Solution

    Covectra Introduces Next-Gen Serialization Solution
    Analytical Services
    Bioanalytical Services
    Bioassay Developement
    Biologics, Proteins, Vaccines
    Biosimilars
    Chemistry
    Clinical Trials
    Drug Delivery
    Drug Development
    Drug Discovery
    Formulation Development
    Information Technology
    Laboratory Testing
    Methods Development
    Microbiology
    Preclinical Outsourcing
    R&D
    Toxicology

    Data Management Trends

    AGC Biologics Expands Cell and Gene Facility in Italy

    Celonic to Boost Cell & Gene Therapy Production

    Pharmaron Acquires Biomanufacturing Site in the UK from AbbVie

    Aptamer Extends Collaboration with AstraZeneca
    Filtration & Purification
    GMPs/GCPs
    Inspections
    QA/QC
    Regulatory Affairs
    Validation

    Guide to Maintaining Validation of Older Facilities: Why, When and How

    The Year of COVID: How FDA Coped with a Worldwide Pandemic in 2020 and What to Expect in 2021

    Top BioPharma Form Accumulus Synergy

    Global Biosciences Co. Selects ValGenesis VLMS

    Gene Therapy Co. Selects ValGenesis' SaaS Platform
    Companies
    Categories
    Corporate Capabilities
    Add New Company
    Contract Service Directory Companies
    Reed-Lane

    Alcami

    Almac Group

    PCI Pharma Services

    Baxter BioPharma Solutions
    Companies
    News Releases
    Posters
    Brochures
    Services
    Videos
    Case Study
    White Papers
    Jobs
    Contract Service Directory Companies
    Syngene

    Almac Group

    Adare Pharma Solutions

    Reed-Lane

    PCI Pharma Services
    Webinars
    Live From Shows
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
      • Enewsletter Archive
      • Digital Edition
    • Directory
      • Companies
      • Categories
      • Corporate Capabilities
      • Add Your Company
    • Manufacturing
      • APIs
      • Aseptic Processing
      • Cleaning Validation
      • Clinical Trial Materials
      • Cytotoxics and High Potency Manufacturing
      • Equipment
      • Excipients
      • Extractables and Leachables
      • Facilities
      • Fill/Finish
      • Lyophilization
      • Parenterals
      • Process Development
      • Process Validation
      • Risk Management
      • Scale-up/ Technology Transfer
      • Solid Dosage/ Creams/ Ointments
      • cGMP Manufacture
    • Packaging
      • Capsules
      • Cold Chain Management
      • Injectables
      • Logistics
      • Serialization
      • Solid Dosage / Semi-solids
      • Supply Chain
      • Vials
    • Development
      • Analytical Services
      • Bioanalytical Services
      • Bioassay Developement
      • Biologics, Proteins, Vaccines
      • Biosimilars
      • Chemistry
      • Clinical Trials
      • Drug Delivery
      • Drug Development
      • Drug Discovery
      • Formulation Development
      • Information Technology
      • Laboratory Testing
      • Methods Development
      • Microbiology
      • Preclinical Outsourcing
      • R&D
      • Toxicology
    • Compliance
      • Filtration & Purification
      • GMPs/GCPs
      • Inspections
      • QA/QC
      • Regulatory Affairs
      • Validation
    • Top 25 Pharma & BioPharma
    • Contract Pharma Direct
    • Breaking News
    • Online Exclusives
    • Slideshows
    • Experts Opinions
    • Surveys
      • Outsourcing Survey
      • Salary Survey
    • Glossary
    • Videos
    • Podcasts
    • White Papers
    • Infographics
    • Contract Pharma Conference
      • Contract Pharma Conference
      • Speakers
      • Exhibitors
      • Conference Sessions
    • Supplier Microsite
      • Companies
      • News Releases
      • Posters
      • Brochures
      • Services
      • Videos
      • Case Study
      • White Papers
    • eBook
    • Webinars
    • Events
      • Industry Events
      • Live from Show Events
      • Webinars
    • Classifieds / Job Bank
      • Classifieds
      • Job Bank
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Features

    Single-use Disposable Systems for Aseptic Fill/Finish

    Today’s disposable systems offer improved manufacturing efficiency, and better QA and regulatory compliance — and they can be the fastest route to media fills

    Related CONTENT
    • Bosch Packaging Technology Introduces Next-Gen HMI 4.0
    • Bosch Packaging Introduces Sigpack VPF, Sigpack HML
    • Packaging Equipment Showcase
    • Idifarma Invests in Automatic Capsule Filling Capabilities
    • CDMO Set for Live Biological Filling Boost
    Robert L. Roy, PE06.06.11

    The introduction of cellulose-based disposable diapers in the early 1960s saved mothers countless hours of rinsing, washing, drying and folding cloth diapers.
    Similarly, single-use disposable systems (SUDS) for aseptic fill/finish units promise to save pharmaceutical manufacturers valuable time, streamlining operations as well as shortening project schedules. Incorporating SUDS can also offer regulatory compliance and environmental, health and safety (EHS) benefits as well as facility design advantages.


    Bulk biotech operations have successfully deployed single-use systems for buffer and media preparations for some time, and they are currently implementing new single-use technologies such as fermentation and chromatography systems. Recent advances in technology are making SUDS increasingly attractive for aseptic operations. A single-use line is a particularly good fit for parenteral solution products with relatively low batch sizes (50L to 500L) that can be transferred by peristaltic pump. 


    Enabling Technologies


    Operations in an aseptic fill/finish line range from the various activities involved in formulation to filtration and solution transfer to dose forming. Today’s disposable systems enable manufacturers to take advantage of this approach throughout the operation. SUD components are available for mixing, addition of liquids or powders, filtration and transfer as well as dosing and sampling. Equipment can be sourced from an increasing number of vendors representing various technologies. Some examples are discussed below:


    Mixing


    Bag mixing systems are available from a number of vendors, including Millipore, Sartorius Stedim Biotech (SSB), Hynetics, ATMI and Xcellerex.  Available single-use technologies include magnetic and disk mixers, as well as levitating impeller technology, all of which use disposable mixing bags. Systems are available in sizes ranging from 10 to 5,000 liters. Disposable feed bags from HicoFlex, HyClone, ATMI and others allow the addition of powders, and single-use sterile connectors in a variety of configurations from Colder, Millipore, Pall, SSB and others enable sterile fluid transfer. 


    Multiple vendors offer single-use bags made of films with low extractables. Most can offer baseline validation packages that, while not product specific, can be used as a starting point for evaluation. Sartorius, for example offers a validation package confirming that its films are designed, manufactured and sterilized under conditions that mirror biopharmaceutical operations and meet current Good Manufacturing Practices (cGMP) requirements. Bags undergo in vitro and in vivo biological reactivity tests and tests for plastic and meet standards for particulate matter in injections, bacterial endotoxins, bioburden and sterilization of medical devices. 


    Bag configurations are customizable, with a wide selection of fittings and tubing. Bags arrive at the facility pre-assembled and sterilized; each batch comes with a certificate of conformance from the manufacturer and a record of sterilization, simplifying documentation requirements. 


    Similarly, a number of vendors offer single-use filtration components in a range of sizes and porosities. For years, these filtration components have been widely used in aseptic fill finish. 


    When evaluating single-use systems, keep in mind that supply chain security is a consideration. Once a specific bag film has been validated for use with a product, continued availability of that film is of paramount importance. The same is true of other components, such as connectors. Manufacturers may wish to pursue parallel qualification of at least two different films for supply chain security. Parallel qualification minimizes associated costs and provides project timeline security in the event that an issue arises with one of the films. 


    Dosing


    A variety of technologies can be considered for single-use dosing systems. Recent improvements in speed and accuracy have made peristaltic filling systems — widely used in clinical filling programs — an attractive alternative to reusable positive-displacement pumps or time/pressure filling systems for commercial-scale dosing of virtually any product. Systems are available from such vendors as Bosch, Groninger, Inova and IMA. 


    From a technical perspective, peristaltic filling provides a simple, inexpensive fluid path and low-shear filling. Servo-drive pumps and advanced pump head geometry improve speed, and today’s peristaltic filling systems are comparable in accuracy to positive displacement systems. At the end of the batch, the tubing is simply removed from the pump head and discarded, eliminating the need to clean the pumps. This offers an ergonomic advantage when the system is used inside an isolator. Tubing on some systems is even designed to be changed out with one hand.  


    Manufacturers who are already committed to a filling technology can still consider single-use options. For those who use rolling diaphragm filling technology, Bosch offers a disposable pre-validated, pre-assembled, pre-sterilized (PREVAS) diaphragm pump, which can be retrofitted to replace stainless steel components on existing lines or purchased for new equipment. Groninger offers a disposable single-use rotary pump. Another option to consider is a system capable of multiple dosing capabilities on the same piece of equipment.  


    Sampling


    Sampling has long involved a single-use approach. Today’s single-use sampling systems are more sophisticated than a disposable sample cup. Sampling systems from Gore, Allpure, Novaseptum and others allow for aseptic single-use sampling for in-process quality control (QC). Although aseptic single-use sampling is relatively new, it has been used successfully in bulk biotech operations for drawing samples from fermenters and similar applications. 


    Positive Impacts on Process


    Throughout the filling and finishing process, SUDS offer several benefits compared to reusable systems. Manufacturers using SUD technology can realize significant increases in process efficiency, with a major reduction in decontamination process requirements and washing/autoclave cycles, as well as elimination of the need for cleaning in place/sterilizing in place (CIP/SIP). As a result, both set-up time and overall turnaround time are reduced. Schedule reliability improves with fewer variables related to cleaning and sterilization. 


    For example, one manufacturer considering single-use technology produces approximately 1,200 batches per year on four to five conventional lines, which utilize CIP/SIP positive-displacement pumps. After each fill is completed, CIP/SIP of the pump station is required, a process that takes five to six hours. The company is testing a single-use peristaltic filling system that would cut turnaround time to approximately one hour, considerably increasing production capacity. Instead of cleaning, it will pull out and discard the used tubing and replace it with pre-assembled, pre-sterilized fresh tubing sets. The switch to SUDS will also result in a huge reduction in the volume of purified water that the company now requires for cleaning.


    Along with enhancing process efficiency, the move to SUDS can also lead to documentation improvements, because fewer batch record documents are necessary.
    With a single-use system, there is an incoming quality assurance/quality control (QA/QC) check when the disposable materials arrive to verify documentation such as Certificate of Conformance from the vendor and sterilization documentation. Another entry is made when a bag or connector is used—but there is no need to generate “after use” records documenting cleaning or sterilization cycles for traceability, or for the time-consuming process of reviewing, approving and correcting the documentation.


    The Project Perspective


    When establishing a new facility or a new production line, the integration of SUDS can streamline the project schedule by reducing or eliminating the need for installation and operational qualification (IOQ) of cleaning equipment and cleaning validation, or performance qualification (PQ) testing requirements. In many cases, SUDS also reduces up-front sterilization validation requirements, for example, by eliminating fill pump/tubing autoclave PQ testing. One of the strongest points in favor of SUDS from a project perspective is the fact that use of disposable technology may lead to faster achievement of a key milestone: media fills. Eliminating the up-front cleaning and sterilizations can easily cut six to eight weeks from the project schedule. 


    In addition to shortening the critical path for project completion, adoption of SUD technology can improve regulatory compliance and environmental, health and safety (EHS) profiles. Inadequate cleaning or sterilization of reusable components can have negative consequences ranging from batch rejection or product recall to plant shutdown—with enormous associated costs. Disposing of components after use reduces the risk of product cross-contamination, thereby improving the facility’s cGMP compliance profile. Pre-assembled, pre-sterilized components also provide a sterile fluid path that improves sterility assurance. 


    Use of disposable components can help increase safety by reducing the potential for operator exposure to highly potent materials that can occur during disassembly and pre-washing of reusable components. With less need for cleaning and chemical neutralization, SUDS can also reduce a facility’s hazardous waste stream and energy costs. SUDS need less water for injection (WFI) and associated equipment, as well as less clean steam. The reduction in energy use can contribute to sustainable design and Leadership in Energy and Environmental Design (LEED) credits. When disposal of single-use components is an issue, at least one vendor can reclaim and pelletize used bag film. 


    Design Advantages


    Use of SUDS can provide great flexibility for both new facilities and retrofits, as space requirements are generally lower and personnel and equipment flows are simpler. 

    A facility that reuses its equipment must be designed to support the proper flow of components from soiled equipment staging, washing, sterilization prep, sterilization and clean equipment staging. It requires large suites for washing, preparation and sterilization. In a reusable facility, soiled equipment must be staged prior to breakdown and cleaning, which requires space. Decontamination can be particularly challenging in a facility that handles biologics, as reusable parts must be decontaminated before cleaning. Operators must use appropriate personal protective equipment (PPE) in order to prevent exposure during disassembly and pre-washing.

    Such a facility needs costly CIP/SIP stations, which usually are placed in a separate room to manage the safety risk associated with their steam lines. The facility also requires cleanroom storage space for staging dirty portable vessels, containers and reusable tubing and hoses as well as large staging areas for clean equipment. Use of disposable parts/systems eliminates or significantly minimizes these issues.


    In general, single-use technologies make it possible to streamline equipment and personnel flows, especially in multi-product facilities. Depending on the extent of SUDS implementation, the capacity requirements of component prep areas can be significantly reduced. With less equipment to wash, the size and number of cabinet washers can be minimized. Without the need to sterilize stainless steel tanks, smaller floor-mounted units can replace pit-mounted autoclaves. Manufacturers working with high-potentcy compounds or live/attenuated viruses will not need to autoclave contaminated single-use components right after usage. SUD equipment can be placed into bags, which are externally decontaminated in vaporized hydrogen peroxide (VHP) chambers prior to internal decontamination elsewhere in central locations for incineration or autoclaving. This method reduces the total number of autoclaves as well as the space required for loading, unloading and maintaining them. Without re-usable portable vessels, there is no need for CIP/SIP stations or chemical storage areas for the corrosive solutions used by them. SUD systems do not need to be product dedicated, eliminating the need for dedicated tanks, hoses and other reusable product-contact parts as well as the space needed to stage them. A SUD system greatly simplifies the flow of materials. The single-use components enter the facility and are kept in a staging area until they are transferred directly to the process manufacturing suite, where they are assembled for production. After production, they may undergo dry fog or VHP decontamination before finally being disposed of through incineration or other means.


    Space requirements can impact both construction and operational costs, and should be considered when weighing a reusable versus single-use approach. For example, in facilities that use reusable product tanks, tuggers are required to transporting heavy tanks from process suites to wash areas. Rooms and corridors must be large enough to accommodate the turning radius of the tugger/tank assemblies, and airlocks must have adequate space to allow interlocked doors to open and close. Door and corridor heights must be sized for the largest vessels. This requirement often drives the need for 10-foot-high doors and 11-foot ceilings to allow for 500- to 800-liter tanks with top-mounted agitators to pass. Most single-use bag mixers are not as tall as these reusable tanks, allowing the use of standard doors and ceiling heights. Reduction in room size and ceiling height reduces the volume of clean air that must be moved through the facility — and thereby reduces the associated energy costs. By allowing for lower ceiling heights, SUDS could cut air volume by 10% or more. 


    Considerations


    Already widespread on the bulk biotech side, SUDS is poised to become commonplace in aseptic manufacturing in the next several years, and customers will come to expect its availability. Organizations looking to design single-use facilities can already take advantage of multiple-vendor sourcing and can choose from proven technologies for various unit operations. The fact that SUDS are mature products makes a change from reusable to disposable a less risky decision. Many key questions—e.g., Can disposable tubing be sterilized by radiation? Will the mixing bags leak?—have already been answered. That being said, there are some challenges to implementation.  


    Product compatibility is one issue. Determining suitability is likely to require new procedures that are outside of the parameters of current stability testing.
    Organizational resources will be challenged to do appropriate testing and provide answers quickly in order to demonstrate suitability for the application. 


    Because it involves a greater change than simply moving a production line from one building to another, switching to SUDS also requires applying more QA and regulatory resources earlier than usual in the project. QA and regulatory staff must be available—often on a full-time basis—to audit suppliers and determine how the move to SUDS will impact documentation packages and affect filing requirements. As noted above, most vendors can supply baseline validation packages to help support this effort. 


    When considering the business case for SUDS, it helps to take a broad view. Various vendors’ analyses have ranged from 50% reductions in operating costs to none. Disposable components are an ongoing expense that will impact the production budget. On the other hand, the savings to be gained through greater process efficiency are significant, and shaving weeks off the project timeline is a huge gain.
    There are also utility savings. And although it is difficult to quantify, the value of decreasing the risk of cross-contamination could be enormous. 


    Proven in various phases of pharmaceutical development, SUDS is proven technology that offers several benefits for aseptic manufacturing. Compared to reusable equipment, SUDS allows the manufacturer to allot less space for washing and sterilizing equipment and for staging parts, and it simplifies management of components and parts. SUDS can help a manufacturer reduce clean utility consumption and possibly reduce operating costs as well. Decontamination is simplified, and personnel and equipment flows within the facility are streamlined. Manufacturers who begin exploring SUDS options now will be ready when clients start requesting the capability. 

     

    Robert L. Roy, PE, is a senior consultant at Integrated Project Services (IPS), a full-service engineering, construction and commissioning & qualification company headquartered in Lafayette Hill, PA. He can be reached at rroy@ipsdb.com.

     

    Jason S. Collins, RA, NCARB is a senior process architect at IPS. He can be reached at jcollins@ipsdb.com.

    Related Searches
    • Validation
    • Parenteral
    • Stability
    • Aseptic
    Suggested For You
    Bosch Packaging Technology Introduces Next-Gen HMI 4.0 Bosch Packaging Technology Introduces Next-Gen HMI 4.0
    Bosch Packaging Introduces Sigpack VPF, Sigpack HML Bosch Packaging Introduces Sigpack VPF, Sigpack HML
    Packaging Equipment Showcase Packaging Equipment Showcase
    Idifarma Invests in Automatic Capsule Filling Capabilities Idifarma Invests in Automatic Capsule Filling Capabilities
    CDMO Set for Live Biological Filling Boost CDMO Set for Live Biological Filling Boost
    Limiting APIs in Manufacturing Effluent Limiting APIs in Manufacturing Effluent
    Walking the Talk at EMD Millipore
Walking the Talk at EMD Millipore
    EHS EHS
    Environmental Health and Safety (EHS) Environmental Health and Safety (EHS)
    Vetter Receives EHS Certification Vetter Receives EHS Certification
    Single-Use Trends Single-Use Trends
    Cambridge Major Laboratories Cambridge Major Laboratories
    IPS IPS
    Catalent Pharma Solutions Catalent Pharma Solutions
    Millipore Opens Bioprocess Facility Millipore Opens Bioprocess Facility

    Related Features

    • Solid Dosage/Semi-solids
      Hygienic Packaging Technology

      Hygienic Packaging Technology

      Growing consumer demand for health products highlights hygienic packaging.
      John Brown, Vice President of Global Marketing, Selig 03.01.21

    • Drug Delivery | Solid Dosage/Creams/Ointments
      Trends in Solid Oral Dosage Delivery

      Trends in Solid Oral Dosage Delivery

      Capsule demand continues to rise due to this delivery system’s versatility.
      Anita Solanki, Milind Biyani and Jnanadeva Bhat, PhD , ACG Capsules 03.01.21

    • Information Technology
      5 Reasons Paper Has No Place in Contract Manufacturing

      5 Reasons Paper Has No Place in Contract Manufacturing

      Digital solutions create more efficient manufacturing processes and eliminate delays.
      Dave Edwards, Chief Revenue Officer, MasterControl 03.01.21


    • Drug Delivery | Parenterals
      Injectable Drug Delivery Trends

      Injectable Drug Delivery Trends

      How medication trends are driving the shift to patient-friendly drug delivery systems.
      Peter Soelkner, Managing Director, Vetter 03.01.21

    • Pharmaceutical Manufacturing  Equipment Trends

      Pharmaceutical Manufacturing Equipment Trends

      Demand for flexibility remains the driving force behind equipment systems.
      Kristin Brooks, Managing Editor, Contract Pharma 03.01.21

    • Drug Delivery | Solid Dosage/Creams/Ointments
      Oral Solids:   Market & Technology Trends

      Oral Solids: Market & Technology Trends

      Oral solids remain the preferred route of drug delivery due to their cost-effectiveness, ease of manufacturing, and patient-friendly dose form options.
      Tim Wright, Editor, Contract Pharma 03.01.21


    • Nutraceutical Manufacturing:  Meeting the Challenges of Today, Planning for  Tomorrow

      Nutraceutical Manufacturing: Meeting the Challenges of Today, Planning for Tomorrow

      Companies continue balancing high demand, supply disruption, and worker safety during the pandemic.
      Sean Moloughney, Editor, Nutraceuticals World 03.01.21

    • 2021 Contract  Manufacturing Survey

      2021 Contract Manufacturing Survey

      Our fourth annual audience poll indicates continued reliance on manufacturing partners, particularly for small businesses.
      Sean Moloughney, Editor, Nutraceuticals World 03.01.21

    • APIs
      Small Molecule Development Trends

      Small Molecule Development Trends

      A Q&A with Cambrex Edinburgh’s site director, Mark Benger.
      Tim Wright, Editor, Contract Pharma 03.01.21


    • APIs | Cytotoxics and High Potency Manufacturing
      Challenges & Opportunities Facing Small & Emerging Biopharma Companies

      Challenges & Opportunities Facing Small & Emerging Biopharma Companies

      A Q&A with Christian Dowdeswell, vice president and head of commercial development for small molecules at Lonza.
      Tim Wright, Editor, Contract Pharma 03.01.21

    • Drug Delivery | Solid Dosage/Creams/Ointments
      Medicated Chewing Gum: A Modern Oral Drug Delivery System

      Medicated Chewing Gum: A Modern Oral Drug Delivery System

      Development and manufacture of medicated chewing gum continues to gain momentum.
      Rukayat Adedeji, Contributing Writer 03.01.21

    • APIs
      Small Molecule API CDMO: A Capital Intensive Business?

      Small Molecule API CDMO: A Capital Intensive Business?

      Exploring small molecule API market trends.
      Dr. Michele Jermini and Dr. Enrico Polastro, Contributing Writers 03.01.21


    • Serialization
      Serialization: Level 5 Solution

      Serialization: Level 5 Solution

      Why a Level 5 solution is required for small pharma companies to fully harness serialization investment.
      Steve Wood, President & CEO, Covectra 03.01.21

    • Solid Dosage/Creams/Ointments
      High Drug Loading Amorphous Solid Dispersions

      High Drug Loading Amorphous Solid Dispersions

      A Novel Tablet Architecture for Amorphous Solid Dispersions to Achieve High Drug Loadings
      Deanna Mudie and Aaron Stewart, Lonza 01.27.21

    • Parenterals
      Parenteral Drug Delivery Trends

      Parenteral Drug Delivery Trends

      A Q&A with Lubrizol Life Science Health’s CDMO Division President, Rob Lee.
      Kristin Brooks, Managing Editor, Contract Pharma 01.27.21

    Trending
    • Four Female Leaders Appointed To Cell & Gene CDMO
    • BMS Expands Cell Therapy Manufacturing Capabilities
    • Reed-Lane Facility Virtual Tour
    • Matica Biotechnology Breaks Ground On Cell And Gene Therapy Site
    • Genesis Drug Discovery & Development Acquires Integrated Analytical Solutions
    Breaking News
    • AGC Biologics Expands Cell and Gene Facility in Italy
    • Celonic to Boost Cell & Gene Therapy Production
    • Pharmaron Acquires Biomanufacturing Site in the UK from AbbVie
    • Aptamer Extends Collaboration with AstraZeneca
    • Fujifilm Breaks Ground on Major Expansion of Biologics Facility in Denmark
    View Breaking News >
    CURRENT ISSUE

    March 2021

    • Hygienic Packaging Technology
    • Trends in Solid Oral Dosage Delivery
    • 5 Reasons Paper Has No Place in Contract Manufacturing
    • Injectable Drug Delivery Trends
    • Pharmaceutical Manufacturing Equipment Trends
    • Oral Solids: Market & Technology Trends
    • Nutraceutical Manufacturing: Meeting the Challenges of Today, Planning for Tomorrow
    • 2021 Contract Manufacturing Survey
    • Small Molecule Development Trends
    • Challenges & Opportunities Facing Small & Emerging Biopharma Companies
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Thymoquinone Inhibits Viral Infection in In Vitro Settings, New Study Finds
    IFT Transitions 2021 Annual Event to Digital Experience
    NY Federal Judge Enters Permanent Injunction Against Dietary Supplement Manufacturer
    Coatings World

    Latest Breaking News From Coatings World

    Sherwin-Williams Announces Resignation of President and COO
    Ashland Completes Expansion and Relocation of Viatel Bioresorbable Polymers Manufacturing Facility
    Evonik Receives Sustainability Award from EcVadis
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Cretex CFO Announces Retirement
    New AI-Based Tool Developed for Coronary Artery Analysis, Intervention Planning
    First Reported Use of Pulse Biosciences' CellFX System
    Contract Pharma

    Latest Breaking News From Contract Pharma

    AGC Biologics Expands Cell and Gene Facility in Italy
    Celonic to Boost Cell & Gene Therapy Production
    Pharmaron Acquires Biomanufacturing Site in the UK from AbbVie
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Ulta Beauty Opens in Herald Square
    Elizabeth Arden Taps Sui He as Global Brand Ambassador
    Natura &Co Outperforms the Global Market in Q4 2020
    Happi

    Latest Breaking News From Happi

    What You're Reading on Happi.com
    Indie Beauty Innovators Wanted
    Cosmetic Chemists Seek Mentors
    Ink World

    Latest Breaking News From Ink World

    Massilly North America Adds Koenig & Bauer MetalStar 3 Metal Decorating Press
    Hydrocarbon Solvents Market to Surpass $8.1 Billion by 2030
    Access Direct Mail Doubles Revenue with SCREEN's Truepress Jet520HD
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Arjobex America welcomes Maggie Naberezny to sales team
    Henkel publishes 30th Sustainability Report
    Avery Dennison Smartrac launches new Circus Pro inlays
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    FPInnovations Develops Biodegradable Mask
    Sani Professional Sanitizing and Disinfecting Products Approved by EPA
    Autefa Solutions Offers Fully Automated Line for Protective Mask Production
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Colfax Decides to Divide Its Businesses
    Stryker Corp.'s 2020 Sales Slip 3.6 Percent
    Bioventus Appoints Managing Director, China and Asia Pacific
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Comercial Kywi Improves Customer Service, Front-Store Operations with Zebra Mobile Solution
    Global Printed Circuit Board Market Projected to Reach $69.32 Billion by 2027
    Global Smart Glass Market to Register 6.8% CAGR Between 2021-28: Grand View Research

    Copyright © 2021 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login