• Login
    • Join
  • FOLLOW:
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Manufacturing
    • Packaging
    • Development
    • Compliance
    • Top 25
    • Directory
    • Microsites
    • Events
    • More
  • Magazine
  • News
  • Manufacturing
  • Packaging
  • Development
  • Compliance
  • Top 25
  • Directory
  • Microsites
  • Events
  • Current / Back Issue
    Features
    Editorial
    Columns
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Subscribe Now
    Advertise Now
    Top Features
    Hygienic Packaging Technology

    Trends in Solid Oral Dosage Delivery

    5 Reasons Paper Has No Place in Contract Manufacturing

    Injectable Drug Delivery Trends

    Pharmaceutical Manufacturing Equipment Trends
    Breaking News
    Online Exclusives
    Industry News
    Collaborations & Alliances
    Promotions & Moves
    Trials & Filings
    Financial Reports
    Bio News & Views
    Custom Sourcing News
    Packaging & Tracking
    CRO News
    Live From Shows
    Top News
    Jubilant Therapeutics Appoints Chief Scientific Officer

    Iontas and Fair Journey Biologics Partner with Quell Therapeutics

    Vetter Establishes Office in China

    AGC Biologics Expands Cell and Gene Facility in Italy

    Celonic to Boost Cell & Gene Therapy Production
    APIs
    Aseptic Processing
    Cleaning Validation
    Clinical Trial Materials
    Cytotoxics and High Potency Manufacturing
    Equipment
    Excipients
    Extractables and Leachables
    Facilities
    Fill/Finish
    Lyophilization
    Parenterals
    Process Development
    Process Validation
    Risk Management
    Scale-up/ Technology Transfer
    Solid Dosage/ Creams/ Ointments

    Vetter Establishes Office in China

    AGC Biologics Expands Cell and Gene Facility in Italy

    Celonic to Boost Cell & Gene Therapy Production

    Pharmaron Acquires Biomanufacturing Site in the UK from AbbVie

    Fujifilm Breaks Ground on Major Expansion of Biologics Facility in Denmark
    Capsules
    Cold Chain Management
    Injectables
    Logistics
    Serialization
    Solid Dosage / Semi-solids
    Supply Chain
    Vials

    Reed-Lane Facility Virtual Tour

    Hygienic Packaging Technology

    Reshaping the Pharmaceutical Supply Chain

    Serialization: Level 5 Solution

    Covectra Introduces Next-Gen Serialization Solution
    Analytical Services
    Bioanalytical Services
    Bioassay Developement
    Biologics, Proteins, Vaccines
    Biosimilars
    Chemistry
    Clinical Trials
    Drug Delivery
    Drug Development
    Drug Discovery
    Formulation Development
    Information Technology
    Laboratory Testing
    Methods Development
    Microbiology
    Preclinical Outsourcing
    R&D
    Toxicology

    Vetter Establishes Office in China

    Data Management Trends

    AGC Biologics Expands Cell and Gene Facility in Italy

    Celonic to Boost Cell & Gene Therapy Production

    Pharmaron Acquires Biomanufacturing Site in the UK from AbbVie
    Filtration & Purification
    GMPs/GCPs
    Inspections
    QA/QC
    Regulatory Affairs
    Validation

    Guide to Maintaining Validation of Older Facilities: Why, When and How

    The Year of COVID: How FDA Coped with a Worldwide Pandemic in 2020 and What to Expect in 2021

    Top BioPharma Form Accumulus Synergy

    Global Biosciences Co. Selects ValGenesis VLMS

    Gene Therapy Co. Selects ValGenesis' SaaS Platform
    Companies
    Categories
    Corporate Capabilities
    Add New Company
    Contract Service Directory Companies
    Almac Group

    Cytovance Biologics

    PCI Pharma Services

    Aphena Pharma Solutions

    Syngene
    Companies
    News Releases
    Posters
    Brochures
    Services
    Videos
    Case Study
    White Papers
    Jobs
    Contract Service Directory Companies
    Alcami

    Emergent BioSolutions

    Syngene

    PCI Pharma Services

    Reed-Lane
    Webinars
    Live From Shows
    • Magazine
      • Current / Back Issue
      • Features
      • Editorial
      • Columns
      • Editorial Guidelines
      • Subscribe Now
      • Advertise Now
      • Enewsletter Archive
      • Digital Edition
    • Directory
      • Companies
      • Categories
      • Corporate Capabilities
      • Add Your Company
    • Manufacturing
      • APIs
      • Aseptic Processing
      • Cleaning Validation
      • Clinical Trial Materials
      • Cytotoxics and High Potency Manufacturing
      • Equipment
      • Excipients
      • Extractables and Leachables
      • Facilities
      • Fill/Finish
      • Lyophilization
      • Parenterals
      • Process Development
      • Process Validation
      • Risk Management
      • Scale-up/ Technology Transfer
      • Solid Dosage/ Creams/ Ointments
      • cGMP Manufacture
    • Packaging
      • Capsules
      • Cold Chain Management
      • Injectables
      • Logistics
      • Serialization
      • Solid Dosage / Semi-solids
      • Supply Chain
      • Vials
    • Development
      • Analytical Services
      • Bioanalytical Services
      • Bioassay Developement
      • Biologics, Proteins, Vaccines
      • Biosimilars
      • Chemistry
      • Clinical Trials
      • Drug Delivery
      • Drug Development
      • Drug Discovery
      • Formulation Development
      • Information Technology
      • Laboratory Testing
      • Methods Development
      • Microbiology
      • Preclinical Outsourcing
      • R&D
      • Toxicology
    • Compliance
      • Filtration & Purification
      • GMPs/GCPs
      • Inspections
      • QA/QC
      • Regulatory Affairs
      • Validation
    • Top 25 Pharma & BioPharma
    • Contract Pharma Direct
    • Breaking News
    • Online Exclusives
    • Slideshows
    • Experts Opinions
    • Surveys
      • Outsourcing Survey
      • Salary Survey
    • Glossary
    • Videos
    • Podcasts
    • White Papers
    • Infographics
    • Contract Pharma Conference
      • Contract Pharma Conference
      • Speakers
      • Exhibitors
      • Conference Sessions
    • Supplier Microsite
      • Companies
      • News Releases
      • Posters
      • Brochures
      • Services
      • Videos
      • Case Study
      • White Papers
    • eBook
    • Webinars
    • Events
      • Industry Events
      • Live from Show Events
      • Webinars
    • Classifieds / Job Bank
      • Classifieds
      • Job Bank
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    India Report

    Growing NDDS Portfolios

    Generic drugs on novel delivery platforms

    Growing NDDS Portfolios
    Related CONTENT
    • Novartis Invests in Credence MedSystems
    • Stevanato Group Launches After-sales Service Offering
    • BD to Invest $1.2B in Pre-Fillable Syringe Manufacturing Capacity
    • Inspecting the Unexpected
    • Stevanato, Catalent Partner to Expedite Equipment Installation
    S. Harachand, Contributing Editor10.11.17
    Development of novel drug delivery systems (NDDS) has accelerated to unprecedented levels today, as the need for drugs having enhanced efficacy and reduced toxicity is becoming greater. Competition in the NDDS marketplace can only intensify with a large number of new products and technologies forecast to enter in the days to come.

    According to estimates by BCC research, the global market for advanced drug delivery systems will reach about $212.8 billion by 2018. NDDS medications contribute to roughly 5-6 percent of India’s pharma market. However, there is no separate regulatory guidance for NDDS products in India.

    For Indian generic firms, NDDS development often grabs the major chunk of their R&D outlay since activity in the drug discovery front is not, usually, a priority area. Compared to drug discovery research, which demands huge investment and time, the cost of developing NDDS-based generic products are far less. Risk of failure with NDDS R&D is small.

    Development timeline is also short. Besides, significantly low production cost, low cost scientific man power and less expensive clinical trials also make NDDS an attractive proposition for Indian drug makers. Already, the generic players have launched several NDDS products in the Indian market after successfully developing platform technologies for a variety of therapeutics. Majority of the leading Indian companies currently have NDDS portfolios. 

    Sun Pharma made headlines in this space when FDA permitted the company to import unapproved liposomal doxorubicin. The company, which launched paclitaxel injection concentrate for nanodispersion using its proprietary Nanotecton platform technology in India, has capabilities in liposomal products, inhalers, lyophilized injections and nasal sprays.

    For oral controlled release drugs Sun uses tech platforms like wrap matrix and gastroretentive innovative delivery (GRID). The company also developed swollen microemulsion and gel free reservoir technology for ophthalmic drugs. The Mumbai-headquartered firm has products including azelastine nasal spray and sumatriptan autoinjector in the U.S. and Europe.

    Dr. Reddy’s targets mainly dermatology and neurology segments for its differentiated formulations. Topical products, injectables and oral modified release dosage forms are Dr. Reddy’s research areas for indications like psoriasis and dermatitis. For neurologic conditions such as migraine, epilepsy and Parkinson’s disease, the company focuses on buccal, sublingual, intranasal and injectable delivery.

    Though many of them have launched oral dosage forms, Indian companies are keen on ocular and parenteral nano delivery systems. Other than liposomes, nano carrier systems include microspheres, niosomes, micelles, nanoemulsions, nanoparticles and dendrimers.

    Even as they try delivery systems unique to each drug, some players lay emphasis on developing formulations with an objective to increase the comfort levels of the patient circumventing invasive administration, minimizing the side effects.

    Zydus Cadila Healthcare landed on the scene by launching an indigenously manufactured diclofenac transdermal patch. Once applied, the skin delivery system provides extended pain relief for 24-hours at a stretch, offering a clear edge over thrice daily oral dosage forms of diclofenac with potential risk of gastric irritation.

    Torrent Pharmaceuticals claims to be the first to develop once-daily formulations for lamotrigine and nicorandil. Torrent leverages proprietary technologies such as dual retard inlay, compact tablet, gastro retentive system and matrix based SR/ modified release formulations, according to the company website.

    India’s fast-emerging NDDS sector has a few pure-play drug delivery systems innovators too.

    Troikaa Pharmaceuticals Ltd., located in Ahmedabad, has established itself in the NDDS arena with a painless version of diclofenac injectable, developed on the company’s patented AquaTech technology platform. With NDDS as mainstay, Troikaa has created several other technologies such as Lipisol that enables oily formulation to become water miscible and matrix tech that helps sustained release of small amounts of active ingredient over an extended period of time from the tablet. Troikaa has been granted a patent for a non-aqueous formulation of diclofenac for topical delivery in over 50 countries including the EU and Japan.

    Obviously, smaller companies including some CMOs are turning their effort on devising delivery modalities for resolving problems with conventional dosage forms of existing molecules or for improving their bioavailability and safety.

    Khandelwal Laboratories, a contract manufacturing company from Mumbai, provides an example. Khandelwal, is working on the areas of colon delivery, brain delivery and osmotically engineered systems controlled delivery to improve efficacy and reduce toxicity mainly for antibiotics, cardiovascular, respiratory and oncology drugs.

    Several players have made technology-sharing arrangement with foreign firms. Companies are also actively pursuing collaborations with academic institutions to boost NDDS research.


    S. Harachand
    Contributing Editor

    S. Harachand is a pharmaceutical journalist based in Mumbai. He can be reached at harachand@gmail.com.
    Related Searches
    • Manufacturing
    • sustained release
    • Drug Delivery
    • Dosage
    Suggested For You
    Novartis Invests in Credence MedSystems Novartis Invests in Credence MedSystems
    Stevanato Group Launches After-sales Service Offering Stevanato Group Launches After-sales Service Offering
    BD to Invest $1.2B in Pre-Fillable Syringe Manufacturing Capacity BD to Invest $1.2B in Pre-Fillable Syringe Manufacturing Capacity
    Inspecting the Unexpected Inspecting the Unexpected
    Stevanato, Catalent Partner to Expedite Equipment Installation Stevanato, Catalent Partner to Expedite Equipment Installation
    Lubrizol Expands Partnership with the Population Council Lubrizol Expands Partnership with the Population Council
    SPI Pharma Appoints CEO SPI Pharma Appoints CEO
    Topical Drugs Poised for Growth Topical Drugs Poised for Growth
    Drug Delivery Market Report Drug Delivery Market Report
    Know the Challenges of Biosimilar Manufacturing Know the Challenges of Biosimilar Manufacturing
    Sterile Manufacturing: Future Trends and Challenges Sterile Manufacturing: Future Trends and Challenges
    Contracting & Outsourcing Session Highlights and Key Takeaways Contracting & Outsourcing Session Highlights and Key Takeaways
    Know the Challenges of  Biosimilar Manufacturing Know the Challenges of Biosimilar Manufacturing
    Marketing Code Round The Corner Marketing Code Round The Corner
    Cancer Trials in the New Age of Drug Development Cancer Trials in the New Age of Drug Development

    Related India Report

    • Drug Delivery | Drug Discovery | R&D

      Discovery: The New Mantra

      R&D spend shoots up as firms turn research savvy
      S. Harachand, Contributing Editor 07.12.16

    • Drug Delivery | Injectables | Lyophilization | Parenterals | Supply Chain | Vials

      Betting Big On Injectables

      Firms hone skills and boost capacities
      S. Harachand, Contributing Editor 06.02.16

    • APIs | Capsules | Chemistry | Drug Delivery | Extractables and Leachables | Facilities | Fill/Finish | GMPs/GCPs | Lyophilization | Process Development | R&D | Toxicology

      CRAMS Rising

      Quality will benchmark growth
      S. Harachand 07.13.11


    • APIs | Capsules | Drug Delivery | Formulation Development

      Solid Footholds in Oral Solids

      Oral dosage business sees surge coming
      S. Harachand 02.25.08

    • Drug Delivery | Injectables | R&D

      Jumping on the Delivery Bandwagon

      Drug research gets NDDS-savvy
      S. Harachand 10.10.07

    Trending
    • Baxter Biopharma Solutions Enters Sterile Manufacturing Agreement For Novavax’ COVID-19 Vaccine
    • Four Female Leaders Appointed To Cell & Gene CDMO
    • Pharmaron Acquires Biomanufacturing Site In The UK From AbbVie
    Breaking News
    • Jubilant Therapeutics Appoints Chief Scientific Officer
    • Iontas and Fair Journey Biologics Partner with Quell Therapeutics
    • Vetter Establishes Office in China
    • AGC Biologics Expands Cell and Gene Facility in Italy
    • Celonic to Boost Cell & Gene Therapy Production
    View Breaking News >
    CURRENT ISSUE

    March 2021

    • Hygienic Packaging Technology
    • Trends in Solid Oral Dosage Delivery
    • 5 Reasons Paper Has No Place in Contract Manufacturing
    • Injectable Drug Delivery Trends
    • Pharmaceutical Manufacturing Equipment Trends
    • Oral Solids: Market & Technology Trends
    • Nutraceutical Manufacturing: Meeting the Challenges of Today, Planning for Tomorrow
    • 2021 Contract Manufacturing Survey
    • Small Molecule Development Trends
    • Challenges & Opportunities Facing Small & Emerging Biopharma Companies
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Diets High In Fructose Could Cause Immune System Damage
    Nestlé Acquires Premium Water Brand Essentia
    Kaneka Probiotics Announces Launch of L. plantarum DR7
    Coatings World

    Latest Breaking News From Coatings World

    Sherwin-Williams Announces Resignation of President, COO
    Ashland Completes Expansion, Relocation of Viatel Bioresorbable Polymers Manufacturing Facility
    Evonik Receives Sustainability Award from EcoVadis
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    FDA OKs First OTC Home Molecular COVID-19 Test
    FDA Approves Second Sight's Argus 2s Retinal Prosthesis
    Cross Border Venture Financing Rose in Final Quarter of 2020
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Sharp Appoints EU Qualified Person
    Baxter Biopharma Solutions Enters Sterile Manufacturing Agreement for Novavax’ COVID-19 Vaccine
    Metrics Contract Services Completes Russian Regulatory Inspection
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    It's International Women's Day—But What Does That Mean?
    e.l.f. Cosmetics and Chipotle Collaborate on Burrito-Inspired Makeup Collection
    Weekly Recap: Sephora Expansion, Ulta Partners with Loop, International Women’s Day & More
    Happi

    Latest Breaking News From Happi

    Cococare Appoints First Woman President
    Ross Highlights Triple Shaft Mixers
    Arm & Hammer Unveils Foot Wipes
    Ink World

    Latest Breaking News From Ink World

    Capital Printing Invests in 2nd Komori Press
    Arna Marketing Adds Canon’s ProStream, VarioPRINT iX Production Inkjet Presses
    Massilly North America Adds Koenig & Bauer MetalStar 3 Metal Decorating Press
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Xeikon details upcoming Xeikon Café TV seminars
    Resource Label Group acquires New England Label
    UV+EB-cured products rated 'easier to recycle'
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Arm & Hammer Launches Foot Wipes
    Kimberly-Clark Names Chief Research and Development Officer
    FPInnovations Develops Biodegradable Mask
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Australia Clears Conformis' iTotal PS Knee Replacement System
    Colfax Decides to Divide Its Businesses
    Stryker Corp.'s 2020 Sales Slip 3.6 Percent
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Comercial Kywi Improves Customer Service, Front-Store Operations with Zebra Mobile Solution
    Global Smart Glass Market to Register 6.8% CAGR Between 2021-28: Grand View Research
    Wearable Patch Market to Reach $27.8 Billion by 2027: Allied Market Research

    Copyright © 2021 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login