Oliver Kappe, Donald Knoechel and Omar Jina10.10.18
In recent years, the FDA has called on pharma and contract manufacturing organizations to switch from batch processes to continuous flow, which offers enhanced control, smaller reaction volumes, and time and cost savings. Continuous flow is particularly suitable for fast, potentially highly exothermic reactions, where safety concerns may prohibit the use of large-scale batch protocols. However, with no commercially available flow calorimeters, measurement of the thermal properties of these reactions remains a challenge. This article discusses how existing high sensitivity calorimetry systems can be adapted to obtain real-time calorimetry data under continuous flow conditions.
The principle of flow chemistry is most easily understood when compared with batch chemistry, the traditional approach for chemical reactions. Batch chemistry involves loading reagents into a single container—often a round bottom flask or jacketed reactor vessel—while heating and stirring to ensure the reaction proceeds to completion. Depending on the process, this is followed by multiple individual steps to separate and purify the final product. In contrast, in flow chemistry,
The principle of flow chemistry is most easily understood when compared with batch chemistry, the traditional approach for chemical reactions. Batch chemistry involves loading reagents into a single container—often a round bottom flask or jacketed reactor vessel—while heating and stirring to ensure the reaction proceeds to completion. Depending on the process, this is followed by multiple individual steps to separate and purify the final product. In contrast, in flow chemistry,
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