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The importance of CAR-T cell therapy in clinical trials: the industry’s evolving, maturing focus
June 4, 2020
By: Panteli Theocharous
Global Vice President, Cell and Gene Therapy Strategy Lead, PPD
Global drug developers in partnership with leading scientists have sharpened focus on advancing the development of CAR-T therapies, expanding applications and improving key logistics of this evolving therapeutic field. In turn, we are seeing three major themes emerging in global discussions about CAR-T in 2020. Seeking more sophisticated CAR engineering for solid tumors CAR-T therapeutics continue to drive the paradigm shift of therapies for patients who are at the end of treatment options for hematological malignancies ranging from palliative to potentially curative. Antigens for CAR-T in liquid tumors are fairly well defined compared to solid tumors, which are much less defined. Therein lies the clinical challenge of translating liquid tumor experience to solid tumor applications. The data supports the need for more sophisticated and scientific engineering of the CAR. Global medical professionals acknowledge the broad potential of CAR-T cell therapy. To date, it has been validated in relapsed and refractory B-ALL malignancies, while the current clinical responses in solid tumors have been sporadic. Solid tumors are a challenge for multiple reasons including:
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