Throughout modern history, humans have been battling infectious diseases. These diseases pose significant global health issues, and the introduction of prophylactic vaccination has been critical in combatting them. The COVID-19 pandemic, caused by the novel SARS-CoV-2 coronavirus, highlights the need for safe and effective vaccines against new pathogens. Dozens of companies and research groups are working on vaccines for COVID-19 as of April 2020.
 
A recent blog post from the CDMO Division of Lubrizol Life Science Health (LLS Health) highlights the historical toll of infectious diseases, uncovers the innate defenses of the immune system, and explains how a vaccine can trigger an adaptive immune response to provide protection against disease. The post also explores how the efficacy and safety of a vaccine are dictated by its formulation and discusses vaccine formulation in the context of the five types of vaccines—highlighting those that require an adjuvant or are based on RNA (ribonucleic acid). In these cases, efficacy can vary by orders of magnitude as a result of exquisitely small changes in the formulation.
 
Click here to read the full blog A Guide to Vaccine Development  from Lubrizol Life Science

Vaccines and vaccination have saved countless millions of lives and changed the face of public health. These programs have limited polio, measles, and tetanus infections and are effective against influenza, HPV, and chickenpox. The development of new products requires an understanding of the pathogen, the immune system, and a deep understanding of vaccine formulation principles—from adjuvants to finished product. LLS Health is a trusted development and manufacturing partner with experience formulating vaccines. If you are looking for a CDMO to help develop your vaccine product or scale-up a manufacturing process in a GMP environment, turn to the knowledgeable, client-focused team at LLS Health.
 
The CDMO Division of Lubrizol Life Science Health is a leading contract development and manufacturing organization. Staffed by experienced CDMO industry experts, the team offers drug product formulation and a comprehensive suite of supporting services including analytic, bioanalytic, physical characterization, and manufacturing. Learn more about our offerings at the links below:

• Formulation and Drug Delivery Technologies
• Drug Product Manufacturing
• Analytical Method Development and Validation
• Feasibility Programs
• Nanomilling
• Microsphere Formulation
• Dexamethasone-Loaded Polymers
• Proprietary Technology
• Our Blog