Development of Pulmonary Dosage Forms for the Successful Delivery of Complex Molecules Pulmonary Drug Delivery

The administration of drugs into the lung is a well-established delivery route for the treatment of a wide range of pulmonary ailments. The direct delivery of drugs to the respiratory tract is ideal for localized treatment of chronic lung diseases such as asthma, chronic obstructive pulmonary disease (COPD), pulmonary hypertension (PA) and for a number of drugs used in the treatment of chronic lung conditions associated with Cystic Fibrosis.

These lung treatments traditionally relied on devices such as metered dose inhalers (MDI’s) and nebulizers to deliver drugs to where they were needed in the lung. In many cases these devices delivered drugs in the upper airways of the lung as well further down the lung architecture.

Whilst these chronic lung conditions will remain a high priority in pulmonary delivery, there is growing interest in delivering drugs deep into the alveolar space, for treatments of diseases within the lung or for subsequent systemic delivery after the drug has crossed the lung epithelium. 

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