Biopharmaceutical molecule pipelines are diversifying, with an increasing number of candidates and new modalities. To keep up with this evolution, cell culture processes are evolving to deliver higher productivity, while increasing the speed to market with reduced risk.

To achieve higher outputs, process engineers need to be ready to work on upstream process intensification and perfusion without forgetting traditional fed-batch, from seed train to the production bioreactor. Therefore, the equipment required needs to offer flexibility in manufacturing modes. Efficiently implementing process intensification requires a combination of several different technologies, namely bioreactors capable of supporting the high cell densities that can be achieved via intensified upstream processing.

The Mobius® iFlex Bioreactor is a scalable family of single-use bioreactors, ranging from 50 L to 2000 L, and suitable for process development and commercial manufacturing. With optional and configurable modules designed to adapt to a variety of control strategies, biopharmaceutical manufacturers can switch from fed-batch to perfusion and be highly responsive to market demand, uncertainty, or a change in strategy.

As a skid ready to integrate into your preferred automation platform, the Mobius® iFlex Bioreactor enables your transition into the automated biomanufacturing Facility of the Future. Single-use bags constructed with high strength Ultimus® film meet the demands of both fed-batch and intensified processes, and perfusion capabilities are within reach with the Cellicon® filter assemblies for perfusion. With best-in-class process analytical technology (PAT) capabilities, the Mobius® iFlex Bioreactor integrates all the sensors your upstream process requires for monitoring and control of critical process parameters. Additionally, the system is ready to connect to Raman analyzers and autosamplers for streamlined analytics for advanced process monitoring and control.

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