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Peptides are very interesting molecules for many applications from therapeutics to cosmetics and diagnostics. But how are they made?
Released By Bachem
October 6, 2021
A peptide is a chain of amino acids, which are used as building blocks. More commonly, peptides are short proteins with varying lengths from 2 amino acids to 100 amino acids. Peptides can be found in nature and can perform biological functions such as acting as messengers in the body. If you are interested in learning more about what a peptide is, please go and read our article. Peptides are very interesting molecules for many applications from therapeutics to cosmetics and diagnostics. But how are they made? Chemical synthesis is the most used method to get these molecules because it brings a lot of advantages. First, it is simpler than biological methods especially for short peptides (up to 60 amino acids). Then the chemical method brings more flexibility in scale, the sequence, and modifications that are applied. In addition to the latter advantages, chemical synthesis enables the production of a peptide that is free of Transmissible Spongiform Encephalopathy/ Bovine Spongiform Encephalopathy (TSE/BSE). Chemical synthesis is also a convenient method to pimp peptides to provide better biological activity. In that regard, synthetic routes open ways to increase the activity of the peptide, to optimize its stability “not better, but longer”. Chemical synthesis offers more possible modifications to minimize side effects or to obtain peptides that are not natural.
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