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The peptide drug market has experienced significant growth in recent years and is expected to continue its upward trend in the coming years.
Released By Bachem
August 1, 2023
The peptide drug market has experienced significant growth in recent years and is expected to continue its upward trend in the coming years. This is supported by a strong pipeline of peptide drugs in development, with many expected to be approved for use in the coming years. In addition to an increasing pipeline, the manufacturing capacity needed for the peptide API is also growing. Indeed, the advent of oral and inhaled peptide products has driven demand for these active pharmaceutical ingredients (APIs). Between 2018 and 2020, the average peptide manufacturing batch size increased 2.3 times in response to a wider variety of peptide drug modalities entering the market. Furthermore, with the launch of new GLP-1 analogs that target metabolic diseases like diabetes and obesity, the need for large-scale manufacturing of these APIs to address large patient populations is growing. Pharmaceutical companies are now under pressure to meet growing needs of generating several hundred kilograms (kg) of peptide active pharmaceutical ingredients (APIs) per year. One significant challenge currently stands in the way of achieving this goal: providing a sustainable, “green” process for large-scale production. Despite the promise of revolutionary new peptide-based therapeutics, producing the necessary quantities of API is a significant challenge, because of chemicals handled. For example, when producing glucagon-like peptides (GLPs) – often used in treatments for diabetes and obesity – up to 16,000 kg (about 35273.92 lb) of chemicals could be needed per kg of APIs manufactured. These manufacturing processes use excessive amounts of solvents and produce considerable quantities of waste, especially the purification step. Therefore, pharmaceutical companies look for a manufacturing partner that can process large-scale demand of a peptide API with:
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