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Peptides have the potential to expand the space of “druggable” targets.
Released By Bachem
February 28, 2023
Peptides have the potential to expand the space of “druggable” targets. No wonder the number of them being under investigation in clinical trials or used as therapeutics is growing. This is accompanied by an increasing need to produce them efficiently and cost-effectively. However, large-scale manufacturing of these active pharmaceutical ingredients (APIs) involves many challenges from decreasing yields when synthesizing molecules with more building blocks to the enormous amounts of solvents needed for synthesis and purification. The only way to make the chemical production of these APIs more efficient and sustainable is to bring new solutions for all steps of the manufacturing processes. This can be achieved either through process optimizations or by using new innovative technologies. There are a variety of ideas and solutions to tackle these challenges. We would like to share a few examples where we have first-hand experience: 1. Automation of SPPS Implementation of a new level of automation and digitalization of solid-phase peptide synthesis (SPPS) to meet the predicted rise in demand for capacity and compliance.
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