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Lilly Agrees to Acquire SiteOne Therapeutics

The transaction includes STC-004, which may represent a next-generation, non-opioid treatment for patients suffering from chronic pain.

Eli Lilly and Company (Lilly) has agreed to acquire SiteOne Therapeutics Inc., a private biotechnology company developing small molecule inhibitors of sodium channels to treat pain and other neuronal hyperexcitability disorders.

The transaction includes STC-004, a Phase 2 ready Nav1.8 inhibitor being studied for the treatment of pain, which may represent a next-generation, non-opioid treatment for patients suffering from chronic pain.

“The global burden of chronic pain continues to increase, and an effective non-opioid treatment remains elusive,” said Mark Mintun, Lilly group Vice President, Neuroscience Research and Development. “Lilly is eager to continue the development of STC-004 with the outstanding SiteOne team as part of our efforts to advance novel, addiction-free pain therapies. Innovation in pain management is critical to address the unmet needs of millions of patients around the world.” 

Under the terms of the agreement, Lilly will acquire SiteOne and SiteOne shareholders could receive up to $1.0 billion in cash, inclusive of an upfront payment and subsequent payments upon achievement of certain regulatory and commercial milestones.

The transaction is subject to customary closing conditions.

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