03.19.15
Eli Lilly and Co. and Hanmi Pharmaceutical Co., Ltd. have entered an exclusive license and collaboration agreement for the development and commercialization of Hanmi's oral Bruton's tyrosine kinase (BTK) inhibitor, HM71224, for the treatment of autoimmune and other diseases. HM71224 is ready to enter Phase II trials and will be investigated for the potential treatment of rheumatoid arthritis, lupus, lupus nephritis, Sjögren's syndrome, and other related conditions.
Lilly will receive worldwide rights for all indications excluding China, Hong Kong, Taiwan, and Korea, and will be responsible for development, regulatory, manufacturing, and commercialization. Hanmi will receive an initial payment of $50 million and is eligible for as much as $640 million in potential development, regulatory, and sales milestones, as well as royalties.
"Significant unmet medical need exists in many prevalent autoimmune diseases where individual patient needs are not adequately being met with available treatments," said Thomas Bumol, Ph.D., senior vice president, biotechnology and immunology research at Lilly. "Lilly is committed to changing patient expectations in some of the world's most debilitating disease areas, and we're building a portfolio of potential advances in immunology through our own research and key collaborations such as with Hanmi. We're highly encouraged by the potential of HM71224 to deliver an innovative, first-in-class treatment option."
"HM71224 is a potent and effective BTK inhibitor and has successfully demonstrated proof of mechanism in preclinical studies and a Phase I study in Europe," said Dr. Gwan Sun Lee, CEO/President of Hanmi Pharmaceutical. He continued, "We are very pleased to be collaborating with Lilly on HM71224, and through this agreement and R&D collaborations, we are excited to drive the joint project forward with the ultimate aim to offer new medical treatment options to patients with autoimmune disorders and related conditions."
Lilly will receive worldwide rights for all indications excluding China, Hong Kong, Taiwan, and Korea, and will be responsible for development, regulatory, manufacturing, and commercialization. Hanmi will receive an initial payment of $50 million and is eligible for as much as $640 million in potential development, regulatory, and sales milestones, as well as royalties.
"Significant unmet medical need exists in many prevalent autoimmune diseases where individual patient needs are not adequately being met with available treatments," said Thomas Bumol, Ph.D., senior vice president, biotechnology and immunology research at Lilly. "Lilly is committed to changing patient expectations in some of the world's most debilitating disease areas, and we're building a portfolio of potential advances in immunology through our own research and key collaborations such as with Hanmi. We're highly encouraged by the potential of HM71224 to deliver an innovative, first-in-class treatment option."
"HM71224 is a potent and effective BTK inhibitor and has successfully demonstrated proof of mechanism in preclinical studies and a Phase I study in Europe," said Dr. Gwan Sun Lee, CEO/President of Hanmi Pharmaceutical. He continued, "We are very pleased to be collaborating with Lilly on HM71224, and through this agreement and R&D collaborations, we are excited to drive the joint project forward with the ultimate aim to offer new medical treatment options to patients with autoimmune disorders and related conditions."