ProBioGen11.17.21
ProBioGen, a premier CDMO, has announced that another product candidate applying its antibody-dependent cellular cytotoxicity (ADCC) enhancement technology GlymaxX has entered clinical development.
Abcuro, a clinical-stage biotechnology company developing therapies for autoimmune diseases and cancer through precise targeting of cytotoxic T cells, recently announced initial data on ABC008, for which ProBioGen generated the production clone applying its proprietary GlymaxX technology and produced the GMP drug substance using its CHO.RiGHT expression and manufacturing platform.
The CHO.RiGHT platform is suited for different kinds of complex biopharmaceuticals. ProBioGen´s sophisticated approach resulted in the generation of a stable, high titer producer clone and the manufacturing of high quality GMP drug substance with strongly enhanced ADCC.
"This phase I clinical trial is an important milestone for Abcuro, and we are proud to have successfully contributed to production of drug substance. We are currently observing a strong increase of ADCC-enhanced product candidates, a high number of which use our GlymaxX technology. Clinical applicability of this approach continues to be demonstrated by our clients," said Dr. Lutz Hilbrich, CEO at ProBioGen.
David de Graaf, Ph.D., Abcuro's CEO added, "ProBioGen is an important partner in the generation of ABC008. Their expertise, passion and dedicated team, along with their innovative GlymaxX technology, provided high-quality drug substance material for our Phase 1 trial."
Abcuro, a clinical-stage biotechnology company developing therapies for autoimmune diseases and cancer through precise targeting of cytotoxic T cells, recently announced initial data on ABC008, for which ProBioGen generated the production clone applying its proprietary GlymaxX technology and produced the GMP drug substance using its CHO.RiGHT expression and manufacturing platform.
The CHO.RiGHT platform is suited for different kinds of complex biopharmaceuticals. ProBioGen´s sophisticated approach resulted in the generation of a stable, high titer producer clone and the manufacturing of high quality GMP drug substance with strongly enhanced ADCC.
"This phase I clinical trial is an important milestone for Abcuro, and we are proud to have successfully contributed to production of drug substance. We are currently observing a strong increase of ADCC-enhanced product candidates, a high number of which use our GlymaxX technology. Clinical applicability of this approach continues to be demonstrated by our clients," said Dr. Lutz Hilbrich, CEO at ProBioGen.
David de Graaf, Ph.D., Abcuro's CEO added, "ProBioGen is an important partner in the generation of ABC008. Their expertise, passion and dedicated team, along with their innovative GlymaxX technology, provided high-quality drug substance material for our Phase 1 trial."