The standard in-vitro assay used to test for endotoxin presence, much preferred over the in-vivo rabbit pyrogen test. LAL is an aqueous extract of blood cells (amoebocytes) from the horseshoe crab, Limulus polyphemus. LAL reacts with bacterial endotoxin or lipopolysaccharide (LPS), which is a membrane component of Gram negative bacteria. This reaction is the basis of the LAL test, which is used for the detection and quantification of bacterial endotoxins.
Glossary
Limulus Amebocyte Lysate (LAL)
02.27.12
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